ISSN:
1432-2013
Keywords:
Atropine
;
Acetylcholine
;
Vascular Smooth Muscle
;
Cholinergic Control of Cerebral Blood Flow
;
Local Arteriolar Reactions
;
Cerebral Arteriolar Resistance
;
Carbachol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In order to evaluate the existence of cholinergic receptors at pial arteries the vasoactive effect of the parasympathomimetic substance carbachol was tested by microapplication into the perivascular space of single pial arteries. Concentration response curves revealed no change in vascular diameter for 10−9 to 10−7 M carbachol. From 10−6 to 10−3 M carbachol dilatations were measured with a maximal reaction at 10−5 M. The carbachol-induced dilatations can be stepwise reduced by ascending pervascular concentrations of atropine thus indicating a competitive antagonism at pial arteries. A cholinergic component influencing pial arterial tone was not found under our experimental conditions since microapplication of atropine (10−9 to 10−4 M) did not induce changes in pial arterial diameter. The dilatation at 10−3 M atropine is believed to be unspecific.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00592597
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