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Interaction retinol-chromatin: an analysis of DNA from vitamin A-treated V79 Chinese hamster cells

Ferrari, N. ; Rocco, M. ; Aprile, A. ; [et al.]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1007 (1989), S. 30-35

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ISSN: 0167-4781

Keywords: (V79 Chinese hamster cell line) ; Chromatin-retinol interaction ; DNA ; Vitamin A

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0167-4781(89)90126-7

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Corticosterone methyl oxidase type II deficiency: a cause of failure to thrive and recurrent dehydration in early infancy (1992)

Picco, P. ; Garibaldi, L. ; Cotellessa, M. ; [et al.]

Springer

European journal of pediatrics 151 (1992), S. 170-173

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ISSN: 1432-1076

Keywords: Corticosterone methyl oxidase type II ; Failure to thrive ; Salt wasting

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Corticosterone methyl oxidase type II (CMO II) deficiency is an uncommon cause of salt-wasting in infancy. We describe a boy who presented with recurrent dehydration and severe failure to thrive in the first 3 months of life, associated with mild hyponatraemia (serum Na+ 127–132 mEq/l) and hyperkalaemia (serum K+ 5.3–5.9 mEq/l). The diagnosis was suggested by an elevated plasma renin activity (PRA): serum aldosterone ratio, and subsequently confirmed by an elevated serum 18-hydroxycorticosterone: aldosterone ratio. Treatment with 9α-fluorohydroxycortisone normalized growth parameters and PRA levels. CMO II deficiency should be considered in infants with recurrent dehydration and failure to thrive, even when serum sodium and potassium levels are not strikingly abnormal.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01954376

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Pressure support ventilation (PSV) reverses hyperinflation induced isorhythmic A-V dissociation (1989)

Conti, G. ; Bufi, M. ; Antonelli, M. ; [et al.]

Springer

Intensive care medicine 15 (1989), S. 319-321

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ISSN: 1432-1238

Keywords: Auto-PEEP ; COPD ; Pressure support ventilation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We report a case of hyperinflation induced isorythmic atrio-ventricular dissociation with circulatory failure in a patient with chronic obstructive pulmonary disease. The arrythmia was successfully treated by applying “pressure support ventilation” (PSV: 20 cmH2O) which, by decreasing the respiratory rate and increasing the expiratory time reduced the level of auto-PEEP. In order to explain this result the Authors recorded, in the same patient, the level of auto-PEEP and ΔFRC obtained with Intermittent Positive Pressure Ventilation (IPPV), Intermittent Mandatory Ventilation (IMV) and PSV at the same gas exchange values. PSV showed a dramatic reduction of both these parameters. (Auto-PEEP: IPPV 12 cmH2O, IMV 17 cmH2O, PSV 7 cmH2O).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00263868

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Auto-PEEP and dynamic hyperinflation in COPD patients during controlled mechanical ventilation and high frequency jet ventilation (1990)

Conti, G. ; Bufi, M. ; Rocco, M. ; [et al.]

Springer

Intensive care medicine 16 (1990), S. 81-84

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ISSN: 1432-1238

Keywords: COPD ; High frequency jet ventilation ; Auto-PEEP

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We investigated the levels of auto-PEEP and dynamic hyperinflation during high frequency jet ventilation (HFJV) and controlled mechanical ventilation (CMV) in six patients with chronic obstructive pulmonary disease within the first 36 h of acute exacerbation. The comparative evaluation was performed at similar conditions of gas exchange in HFJV and CMV: PaO2 77.6±11 mmHg vs 80.8±12 mmHg; PaCO2 46.8±2.5 mmHg vs 47±2.8 mmHg; pH 7.38 vs 7.38. In this situation, the values of auto-PEEP and dynamic hyperinflation, expressed as Δ over the apneic functional residual capacity (FRC) did not differ: (auto-PEEPHFJV 8.9±3.8 cmH2O; auto-PEEPCMV 8.8±4.7 cmH2O; ΔFRCHFJV 0.56±0.19 l; ΔFRCCMV 0.54±0.2 l). This result suggests that, with a suitable machine setting and similar gas exchanges, HFJV produces the same level of auto-PEEP and dynamic hyperinflation as CMV in patients with chronic obstructive pulmonary disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01699850

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Effects of the heat-moisture exchangers on dynamic hyperinflation of mechanically ventilated COPD patients (1990)

Conti, G. ; Blasi, R. A. ; Rocco, M. ; [et al.]

Springer

Intensive care medicine 16 (1990), S. 441-443

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ISSN: 1432-1238

Keywords: Heat-moisture exchangers ; COPD ; Auto PEEP ; Controlled mechanical ventilation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract In recent years the use of devices called Heat and Moisture Exchangers (HME) has become widespread as gas conditioners for ICU patients requiring mechanical ventilation. As an important variation of the resistive properties of the HME, related to flow and duration of use, has recently been pointed out during “in vitro” studies, the use of these devices in COPD patients could increase the levels of auto PEEP and dynamic hyperinflation. In this study we have compared the levels of auto PEEP and difference in functional residual capacity (Δ FRC) in a group of COPD patients, requiring controlled mechanical ventilation (CMV), at basal conditions and after the insertion into the circuit of three HMEs (Dar Hygrobac, Pall Ultipor, Engstrom Edith) at random: the results obtained excluded a significant increase of auto PEEP and Δ (FRC) both with “new” HMEs and after 12 h of continuous use.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01711222

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