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  • Autoimmune haemolytic anaemia  (1)
  • Autopsy frequency  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Alteration of the lung parenchyma associated with autoimmune hepatitis (1991)
    Springer
    Virchows Archiv 419 (1991), S. 153-157 
    Details
    ISSN: 1432-2307
    Keywords: Autoimmune hepatitis ; Chronic interstitial pneumonitis ; Autoimmune haemolytic anaemia ; Endogenous lectins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical history, radiological and histomorphological alterations of the lung parenchyma associated with chronic active autoimmune hepatitis are described. A 6-month-old female infant developed chronic active autoimmune hepatitis associated with autoimmune haemolytic anaemia. She was treated with immunosuppressive drugs, including steroids, for more than 6 years and developed symptoms and radiological signs of interstitial pneumonitis 4 years after onset of the autoimmune hepatitis. Associated bronchiectasis was detected 1 year later. No abnormalities of lung defence mechanisms could be demonstrated. Resection of the sixth left segment and of the basal parts of the left lower lobe revealed honeycombing with changes in the lung parenchyma which included chronic interstitial pneumonitis with multinucleate giant cells, seen predominantly in the distal airways, marked diffuse interstitial mononuclear infiltrates and mild diffuse interstitial fibrosis as well as bronchiectasis and organizing pneumonia. Granulomatous lesions, angiitis and necrotic areas were absent. Immunohistochemistry for immunoglobulins was negative for IgA, IgG and IgM and positive for IgD in the multinucleate giant cells. A strong positive reaction to HLA-DR-specific monoclonal antibody was noted, whereas no specific sugar receptors (endogenous lectins) could be detected by use of biotinylated glyconeoproteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600230
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Incidenz und Obduktionsfrequenz maligner Tumoren von Magen, Colon, Rectum und Lunge — 1900 bis 1975, Raum Heidelberg — (1978)
    Springer
    Virchows Archiv 380 (1978), S. 163-175 
    Details
    ISSN: 1432-2307
    Keywords: Autopsy frequency ; Selection factors ; Stomach-colon-rectum cancer ; Lung-cancer ; Incidences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method for determining the incidence of malignancies of the stomach, colon, rectum, and lungs has been based on the frequency of the tumors in the autopsy material of the Institute of Pathology of the University of Heidelberg for the period 1900 to 1975. The main goal of this model is time independent selection of autopsy material indicated by an almost constant pattern for sex, average age at death, number of inhabitants, and number of autopsies. There is a relationship between incidence and autopsy frequency only when coding the diagnoses independently of their contributions to the cause of death. The results show a nearly constant incidence of stomach cancer, a steady incidence of colon and rectal cancer which, however, differs for men and women, and a large increase in the incidence of lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430623
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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