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Gamma/delta T-cell hepatosplenic lymphoma: review of the literature, diagnosis by flow cytometry and concomitant autoimmune hemolytic anemia (1997)

Sallah, S. ; Smith, S. V. ; Lony, L. C. L. ; [et al.]

Springer

Annals of hematology 74 (1997), S. 139-142

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ISSN: 1432-0584

Keywords: Key words Peripheral T-cell lymphoma ; Hepatosplenic gamma/delta T-cell lymphoma ; Autoimmune hemolytic anemia ; Cold agglutinin disease

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Hepatosplenic gamma/delta T-cell lymphoma is recognized as a subset of peripheral T-cell lymphoma in the REAL classification. Histologically these tumors are characterized by a mixture of small to medium-sized atypical lymphocytes. To date, approximately 15 cases of hepatosplenic γδ T-cell lymphoma have been reported. Affected individuals are usually young adults with a median age of 34 years. Patients commonly present with B symptoms and hepatosplenomegaly, but an absence of lymphadenopathy. The disease follows an aggressive course with median survival of 12–14 months and poor response to combination chemotherapy agents. Occasionally, the occurrence of frank blast transformation constitutes a terminal event for the patient. Although cytopenias are relatively common, nonimmune hemolytic anemia has been reported in one patient only. This is the first report of autoimmune hemolytic anemia associated with hepatosplenic γδ T-cell lymphoma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002770050272

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Dicyclopentadienidhalogenide der Lanthanoide. 7.Teil 6 siehe Lit. [8]. Magnetismus der zwei Modifikationen des Gadolinium-dicyclopentadienidbromids, [Gd(C5H5)2Br]2 und ∞1[Gd(C5H5)2Br]Professor Dietrich Babel zum 60. Geburtstage am 28. Juli 1990 gewidmet (1990)

Handrick, K. ; Schmitz, J. ; Deussen, M. ; [et al.]

Weinheim : Wiley-Blackwell

Zeitschrift für anorganische Chemie 587 (1990), S. 7-15

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ISSN: 0044-2313

Keywords: Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Description / Table of Contents: Dicyclopentadienidehalides of Lanthanides. Part 7. Magnetism of the Two Modifications of Gadolinium-dicyclopentadienidebromide, [Gd(C5H5)2Br]2 and ∞1[Gd(C5H5)2Br]Magnetic susceptibility data of the two modifications of Gd(C5H5)2Br have been determined in the temperature range between 295 and 3 K. Modification I, [Gd(C5H5)2Br]2, is composed of binuclear units (Gd—Gd distance ≈427 pm) whereas II, ∞1[Gd(C5H5)2Br], forms one-dimensional polymers (Gd—Gd distance 488 pm). In either case Curie-Weiss behaviour is observed down to 6 K with magnetic moments close to the Gd3+ free-ion value of Θtheor = 7.94 μB (I: μ = 7.91 μB, Θp = -0.3 K; II: μ = 7.96 μB, Θp = -0.9 K). The behaviour of I which may be affected by an antiferromagnetic coupling of the Gd centres within the binuclear units cannot be described on the basis of isotropic exchange interactions. II exhibits a second Curie-Weiss range below 5 K with a smaller slope compared to the high temperature region.

Notes: Die magnetischen Suszeptibilitäten der beiden Modifikationen von Gd(C5H5)2Br wurden zwischen 295 und 3 K ermittelt. Modifikation I, [Gd(C5H5)2Br]2, besteht aus isolierten Zweikern-Einheiten (Gd—Gd-Abstand: ≈427 pm), während II, ∞1[Gd(C5H5)2Br], eindimensional-unendliche Baugruppen aufweist (Gd—Gd-Abstand: 488 pm). In beiden Fällen wird bis 6 K Curie-Weiss-Verhalten beobachtet mit einem für Gd3+-Ionen (μtheor = 7,94 μB) zu erwartenden magnetischen Moment und kleinen negativen Θp-Werten (I: μ = 7,91 μB, Θp = -0,3 K; II: μ = 7,96 μB, Θp = -0,9 K). I zeigt bei etwa 5 K ein Suszeptibilitätsmaximum, das auf intramolekularen Antiferromagnetismus hinweist. Eine Beschreibung des Verhaltens durch Berücksichtigung isotroper Austauschwechselwirkungen mit Hilfe des Heisenberg-Modells gelingt allerdings nicht. Im Falle von II wird unterhalb 5 K ein zweiter linearer χ-1-T-Verlauf beobachtet.

Additional Material: 4 Ill.