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  • 1
    Electronic Resource
    Electronic Resource
    Pre-embryos (1986)
    [s.l.] : Nature Publishing Group
    Nature 321 (1986), S. 376-376 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Anne McLaren (Nature 320, 570; 1986) states that the human product of conception before the 14th day of intrauterine life should not be called an "embryo" because the cells are destined to develop into both the fetus and the placenta. By implication, experimenting with or throwing away a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/321376b0
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  • 2
    Electronic Resource
    Electronic Resource
    Mast Cells in the Central Nervous System (1966)
    [s.l.] : Nature Publishing Group
    Nature 210 (1966), S. 756-757 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have recently examined the brains of ten hedgehogs (Erinaceus europaeus) in coronal, horizontal and sagittal sections, and found cells apparently identical with mast cells which are localized to the diencephalon. These cells were observed only in the thalamus, epithalamus and metathalamus, and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/210756b0
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of insulin, triiodothyronine and corticosterone on organ cultures of the adult rat cerebellum (1974)
    Springer
    Acta neuropathologica 30 (1974), S. 25-31 
    Details
    ISSN: 1432-0533
    Keywords: Hormones ; Organ Culture ; Cerebellum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fragments of cerebellar cortex from adult rats were maintained as organ cultures for 10 days. Insulin (1.0–1000 μg/ml), triiodothyronine (1.0–1000 ng/ml) and corticosterone (0.1–100 μg/ml) were added to the media of 85 cultures, while 25 with no added hormones served as controls. Survival of neurons and of connective tissue was somewhat improved in the presence of insulin, the optimal level being 100 μg/ml. Triiodothyronine was toxic to all components of the cultures to an extent proportional to the concentration. Corticosterone caused some neuronal damage and suppressed the growth of connective tissue, though these effects were not clearly related to the concentrations in the media. The actions of the hormones on cultured CNS tissue are discussed in relation to their effects on the injured CNSin vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685319
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Vascular permeability associated with axonal regeneration in the optic system of the goldfish (1980)
    Springer
    Acta neuropathologica 51 (1980), S. 39-45 
    Details
    ISSN: 1432-0533
    Keywords: Axonal regeneration ; Central nervous system ; Optic nerve ; Vascular permeability ; Blood-brain barrier ; Teleost fish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An association between axonal regeneration and failure of the blood-brain barrier to plasma proteins has been studied in the goldfish. Vascular permeability was examined by fluorescence microscopy following injection of rhodamine B-labelled bovine serum albumin. Axonal regeneration was studied in adjacent silver-stained sections. Following transection of axons by crushing one optic nerve, it was found that a zone of increased vascular permeability accompanied the advancing front of regenerating axons through the optic nerve, chiasma and tract and into the stratum opticum of the tectum. These observations lend support to a hypothesis in which it is postulated that axons are able to regenerate only when plasma proteins are available to their growth-cones. However, it is also possible that the increased permeability is a consequence rather than a cause of the presence of regenerated axons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688848
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  • 5
    Electronic Resource
    Electronic Resource
    Endoneurial vascular permeability in degenerating and regenerating peripheral nerves (1981)
    Springer
    Acta neuropathologica 53 (1981), S. 181-188 
    Details
    ISSN: 1432-0533
    Keywords: Blood-nerve barrier ; Axonal regeneration ; Nerve injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The endoneurial blood vessels of rodents are normally impermeable to proteins but they become permeable when the axons in the nerve have been severed. In this investigation, the increased permeability is examined in relation to the occurrence or absence of axonal regeneration. The sciatic and hypoglossal nerves of rats were either ligated and transected so that axons would not regenerate, or crushed and then allowed to regenerate. Changes in vascular permeability to fluorescently labelled albumin were examined in the endoneurium distal to the sites of both types of injury at postoperative intervals of 1–21 days. When axonal regeneration was prevented, the endoneurial vessels remained impermeable to the protein tracer until the 6th day. They then became permeable throughout the distal stump and remained so for the remainder of the experimental period. When axons regenerated, there was a considerably more intense exudation of the tracer in the distal segment of the nerve. The zone of greatly increased endoneurial vascular permeability advanced along the nerve at the same rate as that of the most rapidly regenerating axons, as observed in silver-stained sections. It is suggested that in the absence of regenerating axons, vascular permeability may be initiated by products of Wallerian degeneration. The greater permeability in regenerating nerves may be induced by vasoactive substances secreted by growth-cones. The results support a hypothesis in which it is maintained that the presence of plasma proteins around growth-cones is necessary for the occurrence of axonal regeneration. The further increase in permeability caused by the most rapidly elongating axons may assist the regenerative process by making larger quantities of plasma proteins available to other growing axons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688020
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  • 6
    Electronic Resource
    Electronic Resource
    Fluorescent-labelled aprotinin: A new reagent for the histochemical detection of acid mucosubstances (1973)
    Springer
    Histochemistry and cell biology 34 (1973), S. 77-84 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Aprotinin (Trasylol®), a polypeptide protease inhibitor from bovine organs, has been labelled with fluorescein isothiocyanate to produce a fluorecent conjugate (FLA). The conjugate has been applied to paraffin sections of rat tissues and has been shown to act as a specific fluorochrome for acidic mucosubstances. There is reason to believe that FLA stains carbohydrates which owe their acidity to the presence of carboxyl groups. The histochemical findings are described and discussed and it is also suggested that attachment of aprotinin to extracellular polysaccharides in vivo may limit the therapeutic usefulness of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304309
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of metabolic inhibitors on vital staining with methylene blue (1974)
    Springer
    Histochemistry and cell biology 40 (1974), S. 51-57 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The peripheral innervation of murine skin was vitally stained with methylene blue and the effects of various metabolic inhibitors on the staining process were investigated. The observed effects suggest that uptake of the dye is dependent on the integrity of a membrane-associated adenosine triphosphatase and an unidentified metallo-enzyme. Glycolysis, the citric acid cycle and the cytochrome system are not necessary to the process of vital staining, which also does not involve the conduction of nervous impulses or the rapid axoplasmic transport of protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00490273
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  • 8
    Electronic Resource
    Electronic Resource
    Aprotinin, a carbohydrate-binding protein (1973)
    Springer
    Histochemistry and cell biology 34 (1973), S. 275-280 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Evidence is presented for a carbohydrate-binding property of aprotinin, which is preserved both in a fluorescein isothiocyanate (FITC) conjugate and a cyanogen bromidelinked Sepharose conjugate of the protein. Both conjugates similarly retain their tryptic and chymotryptic inhibitory properties. The FITC conjugate is shown to be a single species with respect to charge and to molecular weight and shows a specific binding of normal materials containing sialosyl or uronosyl groups, which accords with its histochemical behaviour. The Sepharose-conjugate showed a similar specificity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306299
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  • 9
    Electronic Resource
    Electronic Resource
    Localization of α-d-glucosyl and α-d-mannosyl groups of mucosubstances with concanavalin A and horseradish peroxidase (1975)
    Springer
    Histochemistry and cell biology 44 (1975), S. 39-45 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Concanavalin A is a lectin which is known to bind specifically to α-d-glucosyl and α-d-mannosyl groups in the mucosubstances of mammalian tissues. The lectin molecule is bivalent; after its attachment to mucosubstances present in a histological specimen it can also bind horseradish peroxidase, a mannose-containing glycoprotein. The attached peroxidase may then be visualized by virtue of its histochemically demonstrable enzymatic activity. Other investigators have utilized this principle in the electron microscopic localization of cell-surface carbohydrates. A histochemical technique for light microscopy is described here, along with three control procedures which establish the specificity of the method. The technique is somewhat more fensitive than earlier ones in which fluorescent-labelled concanavalin A was used, and has the additional advantages that all the required reagents are commercially available and that sacilities for fluorescence microscopy are not needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00490419
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  • 10
    Electronic Resource
    Electronic Resource
    Histochemical detection of the α-D-arabinopyranoside configuration using fluorescent-labelled concanavalin A (1972)
    Springer
    Histochemistry and cell biology 33 (1972), S. 87-94 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A technique is described in which carbohydrates present in sections of animal tissues are stained with fluorescein-labelled concanavalin A. Evidence is presented which suggests that the fluorescent staining is due to the presence of hexose residues containing the α-D-arabinopyranoside configuration. Possible extensions of the application of this type of histochemical method are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304230
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