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  • Chemistry  (2)
  • Polymer and Materials Science  (2)
  • Autologous stem cell transplantation  (1)
  • 1
    ISSN: 1432-0584
    Keywords: Key words Gα16 ; CD34 ; Hematopoietic recovery ; Autologous stem cell transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The hematopoiesis-specific G protein alpha subunit Gα16 was shown to be expressed in early normal and malignant hematopoietic cell lines and has been suggested to play an important role in signal transduction of hematopoiesis. We previously demonstrated a strict correlation of Gα16 mRNA and CD34 antigen expression in peripheral blood stem cells (PBSC). In PBSC mobilization, both markers are detectable at the time of hematopoietic recovery and progenitor cell release. In this study the possible use of Gα16 determination in peripheral blood samples for monitoring patients undergoing stem cell transplantation was investigated. Normal peripheral blood is negative for Gα16 expression. In all five patients Gα16 mRNA expression appeared shortly before the time of blood cell recovery. When tested together with CD34 (three cases) a pattern different from CD34 antigen expression was found, reflecting a different mechanism of action. In two cases with different time points of leukocyte and platelet recovery Gα16 mRNA was detected at both time points but not in the interval, thus suggesting a role of Gα16 in multipotent precursor cells. CD34 mRNA tested in three patients was not detected at any time; this argues for different regulation of CD34 and Gα16 mRNA. Gα16 may be used as an indicator of hematopoietic recovery after autologous stem cell transplantation, suggesting that there are cell type-specific G protein-mediated signal transduction pathways of early hematopoiesis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 19 (1988), S. 289-294 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Test Methods and Dimensioning of Tribologically Loaded PartsOwing to the complexity of tribological systems the testing of wear components is of particular significance. Here is an effort to show the advantages and disadvantages of product tests, component tests and model tests. Even with model tests good results for the products are attainable when relevant parameters are systematically varied. Hereto some examples are given.
    Notes: Wegen der Komplexität tribologischer Systeme ist die Prüfung verschleißbeanspruchter Bauteile von besonderer Bedeutung. Es werden die Vor- und Nachteile der Erzeugnisprüfung, der Bauteilprüfung und der Modellprüfung aufgezeigt. Auch mit Modellprüfungen kann man für die Praxis gute Ergebnisse erzielen, wenn man relevante Parameter systematisch variiert. Hierzu werden einige Beispiele gezeigt.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 20 (1989), S. 14-20 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Fretting Wear The characteristic feature of fretting wear compared with other types of wear lies in the intensive interactions between transfer of debris, mode of vibration and wear. In particular, the forms of wear are heavily dependent on the continued presence or removal of the resulting wear particles and on the accessibility to lubricants. The systematic treatment of the individual forms of wear facilitates the analysis in cases of damage. Despite the system dependence of wear, the methods of the test chain and of parameter variation makes it possible to achieve practical test results also with component and model tests. An example shows how the quality of tribologically stressed components can be systematically improved in this way.
    Notes: Das charakteristische Merkmal der Verschleißart Schwingungsverschleiß gegenüber anderen Verschleißarten ist die intensive Wechselwirkung zwischen Stofftransport, Schwingungsform und Verschleiß. Insbesondere die Verschleißerscheinungsformen werden stark vom Verbleib oder Abtransport der entstehenden Verschleißpartikel und den Schmierstoffzutrittmöglichkeiten beeinflußt. Eine systematische Behandlung der einzelnen Verschleißerscheinungsformen erleichtert die Analyse von Schadensfällen. Trotz der Systemabhängigkeit des Verschleißes bieten die Methoden der Prüfkette und der Variation der Parameter die Möglichkeit, auch mit Bauteil- und Modelltests praxisnahe Prüfergebnisse zu erzielen. In einem Beispiel wird gezeigt, wie man damit die Qualität tribologisch beanspruchter Bauteile systematisch erhöhen kann.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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