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  • 1
    ISSN: 1432-0878
    Keywords: Hypothalamic neurosecretory system (rat) ; Adrenal cortex ; 35S-cysteine incorporation ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The incorporation of 35S-labelled cysteine in the hypothalamic-neurohypophyseal system was studied in normal and adrenalectomized rats and in rats treated with excess hydrocortisone. Labelled cysteine was intraperitoneally administered and grain counts were made of autoradiographs produced from sections of the supraoptic and paraventricular nucleus, median eminence and neurohypophysis of animals killed 45 min., 4 hours and 24 hours after administration of the labelled substance. On the whole, lower incorporation levels of the label were noted in the adrenalectomized rats, compared with the controls. In the rats treated with excess hydrocortisone, the grain counts at 45 min and 4 hours after injection were higher and those at 24 hours were lower than those of the controls. The findings are discussed, among other things, in terms of rate of uptake vs. time and related to previous reports on the cysteine uptake and neurosecretory activity of the hypothalamic-neurosecretory sytem.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 163 (1975), S. 125-132 
    ISSN: 1432-0878
    Keywords: Bovine subcommissural organ ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The bovine subcommissural organ was studied by using scanning electron microscopy. The most prominent finding was the existence of protruded and dilated endings of the ependymal cells. The majority of these cells were ciliated with two or more cilia; only a few unciliated cells were seen. Some pore-like structures were also seen on the surface. From the functional point of view, the most interesting finding was an amorphous heterogeneous material on the subcommissural ependyma. Especially in the caudal part of the organ this material accumulated in abundance. No real filamentous structures such as Reissner's fibre could be seen, however, it was assumed that the heterogeneous material corresponds to this formation. No supraependymal neurones were demonstrated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 115 (1971), S. 110-113 
    ISSN: 1432-0878
    Keywords: Hypothalamic-hypophyseal system ; Cysteine incorporation ; Dehydration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of dehydration upon incorporation of 35S-labelled 1-cysteine in the hypothalamic-hypophyseal neurosecretory system of the rat was studied by autoradiography. Grain counts were made of the supraoptic and paraventricular nuclei, median eminence and neurohypophysis. The results were statistically treated. The effect of dehydration was observed, at first, as an increase of incorporation in all the sites examined. Six hours after administration, the disappearance of the isotope from the nuclei was accelerated, and after 24 hours also that from the distal parts of the neurosecretory system. The results are interpreted, in the first place, in terms of activation of the neurosecretory system caused by dehydration.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 124 (1972), S. 342-353 
    ISSN: 1432-0878
    Keywords: Hypothalamic-hypophyseal neurosecretory tracts (rat) ; Incorporation of 35S-cysteine ; Kinetics of neurosecretory material ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fate of 35S-cysteine incorporated into the hypothalamic-hypophyseal neurosecretory system was followed in normal rats as a function of time from 30 min up to 30 hrs after intraperitoneal administration (11 different times, three rats each). Autoradiography and grain counting were employed to determine quantitatively the activities present in: supraoptic nucleus (SON), paraventricular nucleus (PVN), three different sites in the hypothalamic-hypophyseal tract (HHT), corresponding to its initial, middle and late portions, and neurohypophysis (NH). In SON and PVN, the kinetic behaviour of 35S-cysteine was compatible with a two-compartment model, implying decline of tracer activity in accordance with two exponential components. Of these, the slow throughput component had its closely equivalent, apparently independent, counterparts in the HHT and NH. Replicas of the rapidly abating activity peak were seen, superimposed on the slow component, in the HHT with such timing of its appearance at the various sites, as to be consistent with the concept of travel through the HHT, at substantially constant speed and without delay, of material rich in 35S-cysteine that has been primarily synthesized in the SON and PVN (with the “transport theory of neurosecretion”). This flow was calculated to have a velocity in the order of 0.6 mm per hour. The kinetic phenomena and their association with the supposed sites of synthesis, and transport, of the neurosecretory material are discussed with reference to earlier literature.
    Type of Medium: Electronic Resource
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