Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Engineering General  (3)
  • Autoradiography  (1)
  • Dopamine  (1)
  • 1
    ISSN: 0167-0115
    Keywords: Antagonist ; Autoradiography ; Human ileum ; NK"2 receptor ; Radioligand binding ; Rat brain ; Tachykinin ; [^3H]GR100679
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-2072
    Keywords: Key words Prepulse inhibition ; Sensorimotor gating ; Auditory discrimination task ; Go/NoGo procedure ; Selective attention ; d-Amphetamine ; Dopamine ; Schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Rationale: Prepulse inhibition (PPI) of the startle reflex is a measure of sensorimotor gating, that is the processing of the startle stimulus (S2) is inhibited by the interfering processing of a closely preceding prepulse (S1). It has been demonstrated that PPI is disrupted in a variety of mental disorders and that several neurotransmitter systems, including dopamine, participate in the modulation of sensorimotor gating. Previous studies have also shown that a task-relevant S1 enhances PPI in healthy subjects but not in schizophrenic patients. These findings indicate an influence of attentional processes on sensorimotor gating and an impairment of this modulation in schizophrenia. Objective: Assuming a dopamine-mediated suppression of S1 processing as a mechanism of resource management and selective attention, which might be impaired in certain mental disorders, the present study investigated the effects of the indirect dopaminergic agonist d-amphetamine on prepulse-altered S2 discrimination and event related potentials (ERPs). Methods: Twelve healthy volunteers were tested in a double-blind, placebo-controlled experimental design. Here, S2 is the target in a difficult Go/NoGo auditory discrimination task. Results: Confirming our previous results, S2 processing is ”accentuated” by a weak acoustic prepulse in healthy subjects, thus leading to a lower rate of errors of omission but also to more false alarms (i.e. a liberal response bias). This performance change correlated with a prepulse-induced increase in the amplitude of the P3 ERP towards non-targets (”prepulse-induced non-target positivity”; PINTP). In addition, the results of the present study show that under prepulse conditions amphetamine disrupts ”S2 accentuation” associated with a dose-related reduction of the P2 component of the S1 response and a plasma level related reduction of PINTP. Conclusions: These data suggest an involuntary attentional shift towards S1 processing with increasing dopamine-release similar to that observed in patients with schizophrenia or OCD. It is concluded that sensory gating alters selective attention via dopaminergic modulation.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 11 (1977), S. 1261-1269 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The non-linear steady state response of structures with curvature is investigated through the expository example of a shallow circular arch. A consistent mass finite element formulation is employed to derive the governing non-linear differential equations.These equations are solved by assuming a single mode expansion reducing the governing equations to the single degree-of-freedom Duffing's equation with a quadratic term. The non-symmetric amplitude-frequency curve is derived and compared with results previously obtained by direct integration of the equations of motion.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 15 (1980), S. 779-789 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: An accurate and economical eight-node quadrilateral membrane element based on stress assumptions is presented. It is shown that this element offers distinct advantages over other available membranes.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 3 (1983), S. 23-31 
    ISSN: 0271-2091
    Keywords: Finite Element ; Navier-Stokes ; Incompressible Flows ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A variational formulation for the solution of two dimensional, incompressible viscous flows has been developed by one of the authors.1 The main objective of the present paper is to demonstrate the applicability of this approach for the solution of practical problems and in particular to investigate the introduction of boundary conditions to the Navier-Stokes equations through a variational formulation. The application of boundary conditions for typical internal and external flow problems is presented. Sample cases include flow around a cylinder and flow through a stepped channel.Quadrilateral, bilinear isoparametric elements are utilized in the formulation. A single-step, implicit, and fully coupled numerical integration scheme based on the variational principle is employed. Presented results include sample cases with different Reynolds numbers for laminar and turbulent flows. Turbulence is modelled using a simple mixing length model. Numerical results show good agreement with existing solutions.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...