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  • Autoreceptors  (2)
  • Hyperactivity  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    SKF 38393 potentiates yawning induced by LY 171555: further evidence against the autoreceptor hypothesis of yawning (1989)
    Springer
    Psychopharmacology 98 (1989), S. 567-568 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine ; Yawning ; Autoreceptors ; LY 171555 ; SKF 38393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of concurrent D-1 receptor stimulation by SKF 38393 on the expression o yawning elicited by D-2 receptor stimulation with LY 171555 was studied in the rat. A low dose of SKF 38393 (2.5 mg/kg SC), while failed to elicit yawning, potentiated the effectiveness of LY 171555 in eliciting yawning at all the doses tested (12.5, 25 and 50 μg/kg SC) and this effect was abolished by SCH 23390 (0.012 mg/kg SC). The results indicate that in analogy with typical post-synaptic dopaminergic effects (hypermotility-stereotypy), yawning elicited by a D-2 agonist is facilitated by concurrent stimulation of D-1 receptors and therefore is consistent with previous evidence that yawning in response to a D-2 agonist is not mediated by autoreceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441963
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Antagonism of apomorphine-induced yawning by SCH 23390: Evidence against the autoreceptor hypothesis (1986)
    Springer
    Psychopharmacology 89 (1986), S. 259-260 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Autoreceptors ; Dopamine ; SCH 23390 ; Yawing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of apomorphine to induce yawning (YWG) in normal and reserpinized rats and its interaction with SCH 23390, a potent and specific D-1 receptor antagonist, was studied. Apomorphine was more potent in inducing YWG in reserpine-pretreated as compared to control rats. SCH 23390, in low doses (0.05 mg/kg SC), was able to significantly reduce the YWG evoked by apomorphine both in control and in reserpine-pretreated rats. The results indicate that D-1 receptors contribute to YWG elicited by apomorphine and contradict the idea that this effect is mediated by DA autoreceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310640
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Dopaminergic D-1 receptors: essential role in morphine-induced hypermotility (1987)
    Springer
    Psychopharmacology 93 (1987), S. 401-402 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Dopamine ; Hyperactivity ; D-1 receptor ; SCH 23390 ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of morphine HCl (20 mg/kg SC) to male C57B1/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00187265
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    Paper (German National Licenses)
    Fulltext
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