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  • 1
    Electronic Resource
    Electronic Resource
    Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos (1990)
    Springer
    Diabetologia 33 (1990), S. 593-596 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic embryopathy ; myo-inositol ; prostaglandins ; neural tube ; mouse embryos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neural tube defects in infants of diabetic mothers constitute an important and frequent cause of neonatal mortality/morbidity and long-term chronic handicaps. The mechanism by which normal neural tube fusion occurs is not known. The failure of rostral neural tube fusion seen in mouse embryos incubated in the presence of excess-D-glucose can be significantly prevented by the supplementation of myo-inositol to the culture medium. This protective effect of myo-inositol is reversed by indomethacin, an inhibitor of arachidonic acid metabolism leading to prostaglandin synthesis. Prostaglandin E2 added to the culture medium completely protects against the glucose-induced neural tube defect. These data suggest that the failure of neural tube fusion seen in diabetic embryopathy is mediated through a mechanism involving abnormalities in both the myo-inositol and arachidonic acid pathways, resulting in a functional deficiency of prostaglandins at a critical time of neural tube fusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400202
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Serum arginine-vasotocin (AVT) and afferent and central control of osmoregulation in conscious Pekin ducks (1980)
    Springer
    Pflügers Archiv 387 (1980), S. 99-106 
    Details
    ISSN: 1432-2013
    Keywords: Avian ADH ; Avian osmoregulation ; Cerebral osmosensitivity ; Hypothalamic temperature ; Vagal afferents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In conscious Pekin ducks adapted either to fresh water or to hypertonic saline (1.9%) as drinking fluid, urinary excretion, salt gland secretion and the serum concentration of radioimmunoassayable arginine-vasotocin (AVT) were examined with regard to their afferent and central control. The experiments were carried out under conditions of water diuresis, osmotic diuresis or supraorbital salt gland secretion, which were induced by continuous infusions of appropriate solutions. Temporary bilateral vagus blockade caused rises in AVT serum concentration accompanied by antidiuresis in hydrated ducks and by inhibition of salt gland secretion in salt-stressed ducks. Rostral brainstem cooling caused decreases of AVT serum concentration and water diuresis in ducks under osmotic diuresis and reduction of AVT serum concentration and inhibition of salt gland secretion in saltstressed ducks. Cerebral osmotic stimulation in hydrated ducks by intracarotid injection or by intracerebroventricular microinfusion of hypertonic NaCl solutions caused antidiuretic reactions associated with rises of AVT serum concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584259
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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