ISSN:
1432-2072
Keywords:
Learning
;
d-Amphetamine
;
Brain Catecholamines
;
Avoidance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two-way avoidance conditioning was compared in three strains of rats: Roman high avoiders (RHA), Roman low avoiders (RLA) and control Sprague-Dawleys (SD). RHAs performed more and RLAs fewer avoidance responses than SDs. RLAs injected with d-amphetamine improved their performance to levels comparable to SDs; however, d-amphetamine caused a time-dependent increase in intertrial crossings for the RLAs. Of the three strains, the RLAs had the lowest activities of tyrosine hydroxylase, dopamine-Β-hydroxylase and phenylethanolamine-N-methyltransferase in their adrenal glands. Although there were no significant differences among the strains in respect to tyrosine hydroxylase activity in whole brain or regions, RLAs had higher dopamine-Β-hydroxylase activity in the whole brain and cerebral cortex as compared to the SDs. RLAs and RHAs together had a significantly different turnover of intracisternally administered 3H-norepinephrine than SDs. After the intracisternal injection of 3H-L-tyrosine, twice as much 3H-dopamine accumulated in the brains of RLAs as compared to RHAs and SDs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429296
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