ISSN:
1432-2072
Keywords:
Avoidance
;
Impairment
;
Relationship
;
Antagonism
;
Synergism
;
Imipramine
;
Carbidin
;
Amphetamine
;
Chlorpromazine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The relationship between amphetamine and a new psychotropic drug, carbidin (in comparison with imipramine and chlorpromazine) was studied on a test of activity and the passiv avoidance conditioned response. Carbidin and imipramine woud appear to differ from chlorpromazine in their mode of action on conditioned response. Looking at the interactions between amphetamine and the other drugs in the two tests differences in the mode of action of carbidin and imipramine becomes apparent. Whereas in the passive avoidance conditioning situation both drugs had similar effects alone and in combination with amphetamine in the activity test, though both are without effect when given alone, in combination with amphetamine the interactions are in opposite directions. Imipramine has a synergistic effect, whereas carbidin has marked antagonistic affect completely reversing the amphetamine induced increase in activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00403999
Permalink
