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  • 1
    ISSN: 1432-0533
    Keywords: Key words ALS ; CuZnSOD ; MnSOD ; Immunoantibodies ; Brain stem motor neurons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Motor neurons from the brain stems of amyotrophic lateral sclerosis (ALS) and control patients were examined with immunoantibodies to CuZn-superoxide dismutase (CuZnSOD) and Mn-superoxide dismutase (MnSOD). We found that there was a marked staining for CuZnSOD in all the motor nuclei, the hypoglossus, ambiguus, facialis and trigeminus from the ALS patients, but not in the controls. The same neurons from the ALS patients also stained very intensely for MnSOD, whereas the neurons from the control patients stained weakly or not at all. Loss of neurons was also a very consistent finding and was noted in all the motor nuclei from the ALS patients. There was a proliferation of glial cells which stained strongly both for CuZnSOD and for MnSOD accompanying the loss of the neurons. These results indicated that there was an apparent increase of superoxide dismutase immunoreactivity in motor neurons of ALS patients. We conclude that CuZnSOD and MnSOD immunoreactivity is increased in motor neurons and glia in the brain stems of patients with ALS, specific for the terminal phase of this disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 11 (1968), S. 275-281 
    ISSN: 1432-0533
    Keywords: RNA ; Nerve Cell ; Axon ; Iminodipropionitrile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der RNS-Gehalt einzelner Nervenzellkörper aus dem Vorderhorn des Rückenmarks der Ratte zeigt keine Zunahme während der 12 wöchigen IDPN (β,β-Iminodipropionitril)-Fütterung, doch wurde während der letzten 4 Wochen eine geringe Verminderung beobachtet. Die RNS-Konzentration in den Axon-Ballons beträgt 0,23%, verglichen mit 5,3% in den Nervenzellkörpern. Der Adenin/Uracil (A/U)-Quotient der RNS in den Axonballonen beträgt 0,61 gegenüber 0,90 in den Perikaryen der normalen Nervenzellen. Der A/U-Quotient von RNS in den Zellkörpern von Ratten, die mit IDPN gefüttert wurden, ist auf 0,68 reduziert (6–8 Wochen), während er für Ratten, die 1–12 Wochen lang mit IDPN gefüttert wurden, 0,77 beträgt.
    Notes: Summary The RNA content of single nerve cell bodies from the anterior horn of rat spinal cord shows no increase during the 12 weeks of feeding of IDPN (β,β-iminodipropionitrile), but a slight decrease is noted during the last four weeks. The RNA concentration in the axonal balloons is only 0.23% as compared to 5.3% in the nerve cell body. The A/U ratio of RNA in the axonal balloons is 0.61 as compared to 0.90 in cell bodies of normal nerve cells. The A/U ratio of RNA in cell bodies of rats fed IDPN is also reduced to 0.68 (6–8 weeks) while the A/U for rats fed IDPN for 1–12 weeks is 0.77.
    Type of Medium: Electronic Resource
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