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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Acta neuropathologica 95 (1998), S. 625-631 
    ISSN: 1432-0533
    Schlagwort(e): Key words Shaken baby syndrome ; Shaken infant ; Axonal injury ; β-Amyloid precursor protein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We examined an autopsy series of 14 children with shaken baby syndrome (SBS) who lacked skull fracture. Evidence of axonal injury was sought using immunohistochemical stains for neurofilament, 68-kDa neurofilament and β-amyloid precursor protein (βAPP). βAPP-positive axons were present in the cerebral white matter of all cases of SBS but were also present in 6 of 7 children dying of non-traumatic hypoxic ischemic encephalopathy (HIE). Swollen axons were present in 11 of 14 cases of SBS and in 6 of 7 cases of HIE. βAPP-positive axons were present in both groups in the midbrain and medulla. The cervical spinal cord in SBS contained βAPP-positive axons in 7 of 11 cases; 5 of 7 contained swollen axons within the white matter tracts; in 2 immunoreactivity was localized to spinal nerve roots; in all 7 there was a predilection for staining at the glial head of the nerve root. Among cases of HIE, none showed abnormal axons or βAPP-positive reactivity in the cervical cord white matter. We conclude that cerebral axonal injury is common in SBS, and may be due in part to hypoxic/ischemic injury. Cervical cord injury is also common, and cannot be attributed to HIE. These findings corroborate suggestions that flexion-extension injury about the cervical spinal column may be important in the pathogenesis of SBS.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1573-1561
    Schlagwort(e): Pest control agent ; plant extract ; Trewia nudiflora ; trewiasine ; control agent ; antifeedant ; morphogenic agent
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract An ethanol extract ofTrewia nudiflora (Euphorbiaceae) seed was tested as an agent for controlling several economically important insects. Results suggest that this plant extract acts as an antifeedant for the spotted cucumber beetle (Diabrotica undecimpunctata howardi Barber) and the European corn borer [Ostrinia nubilalis (Hübner)] but not for the other insects tested. Also indicated were morphogenic effects on the codlingmoth [Laspeyresia pomonella (L.)], disruption of the normal life cycle of the redbanded leafroller [Argyrotaenia velutinana (Walker)], and reduction in the progeny of the plum curculio [Conotrachelus nenuphar (Herbst)]. In addition, the extract was toxic to the striped cucumber beetle [Acalymma vittatum (F.)] and gave 100% control of the chicken body louse [Menacanthus stramineus (Nitzsch)] from 5 to 28 days. Fractionation of the extract was monitored by a bioassay usingO. nubilalis. This fractionation yielded six pure compounds, the most abundant of which was trewiasine. Its LD50 was 7.4 ppm when incorporated into the diet ofO. nubilalis. Dose-mortality relationships for the other compounds withO. nubilalis are presented.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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