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  • 1
    Electronic Resource
    Electronic Resource
    Premorbid adjustment and remission of positive symptoms in first-episode psychosis (1997)
    Springer
    European child & adolescent psychiatry 6 (1997), S. 212-218 
    Details
    ISSN: 1435-165X
    Keywords: First-episode psychosis ; schizophrenia ; positive symptoms ; premorbid adjustment ; course
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The impact of premorbid social and intellectual functioning in childhood and early adolescence on the developmental course of schizophrenia is not sufficiently understood. In a retrospective case study (93 consecutive in-patients, 43 males and 50 females) of first-episode psychosis occurring in adolescence, the relationship between premorbid adjustment and short-term therapeutic outcome under treatment conditions was examined. All of the patients had a DSM-111-R diagnosis of schizophrenia (n=56) or schizoaffective disorder (n=37). The mean age of the patients at the time of the study was 15.8 (SD=1.0). Premorbid functioning during childhood and early adolescence was assessed by using the Cannon-Spoor et al. Premorbid Adjustment Scale (PAS) and studied with respect to its prognostic relevance for short-term therapeutic outcome (eight weeks) under neuroleptic treatment (350–700 mg Chlorpromazin dose equivalent). Criteria for clinical outcome were obtained from the study by Pearlson et al. (1989) which defines three grades (complete remission, partial remission and no response), according to the degree of positive symptomatology. Statistical analysis was based on nonparametric variance analysis. Patients with complete remission of positive symptoms after eight weeks of therapy had experienced far better premorbid adjustment in early adolescence and in childhood. Diagnosis and gender did not bias this result. Our data suggest that premorbid social functioning is a crucial variable with regard to therapeutic outcome in first-episode psychosis. Previous studies have reported a relation between poor premorbid functioning and negative symptoms. We found premorbid adjustment related to the course of positive symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539928
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Premorbid adjustment and remission of positive symptoms in first-episode psychosis (1997)
    Springer
    European child & adolescent psychiatry 6 (1997), S. 212-218 
    Details
    ISSN: 1435-165X
    Keywords: Key words First-episode psychosis ; schizophrenia ; positive ; symptoms ; premorbid adjustment ; course
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The impact of premorbid social and intellectual functioning in childhood and early adolescence on the developmental course of schizophrenia is not sufficiently understood. In a retrospective case study (93 consecutive in-patients, 43 males and 50 females) of first-episode psychosis occurring in adolescence, the relationship between premorbid adjustment and short-term therapeutic outcome under treatment conditions was examined. All of the patients had a DSM-III-R diagnosis of schizophrenia (n=56) or schizoaffective disorder (n=37). The mean age of the patients at the time of the study was 15.8 (SD=1.0). Premorbid functioning during childhood and early adolescence was assessed by using the Cannon-Spoor et al. Premorbid Adjustment Scale (PAS) and studied with respect to its prognostic relevance for short-term therapeutic outcome (eight weeks) under neuroleptic treatment (350–700 mg Chlorpromazin dose equivalent). Criteria for clinical outcome were obtained from the study by Pearlson et al. (1989) which defines three grades (complete remission, partial remission and no response), according to the degree of positive symptomatology. Statistical analysis was based on nonparametric variance analysis. Patients with complete remission of positive symptoms after eight weeks of therapy had experienced far better premorbid adjustment in early adolescence and in childhood. Diagnosis and gender did not bias this result. Our data suggest that premorbid social functioning is a crucial variable with regard to therapeutic outcome in first- episode psychosis. Previous studies have reported a relation between poor premorbid functioning and negative symptoms. We found premorbid adjustment related to the course of positive symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00539928
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Transport des Hydroxyanalogons von Leucin in Bürstensaum-Membranvesikel des Kaninchendünndarms (1991)
    Springer
    European journal of nutrition 30 (1991), S. 233-237 
    Details
    ISSN: 1436-6215
    Keywords: Hydroxyanaloga von Aminosäuren ; H+-Ionen-stimulierter Transport ; Bürstensaum-Membranvesikel ; hydroxy analogues of amino acids ; proton driven transport ; brushborder membran vesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Hydroxy analogues of essential amino acids can be used in clinical nutrition to minimize nitrogen intake. In this study intestinal uptake of L-leucine hydroxy analogue into rabbit jejunal brush-border membrane vesicles was investigated. An inward directed H+-gradient was a driving force of uptake (pHoutside = 6.0; pHinside = 7.5) and led to a transient accumulation. The saturable system has a apparent transport constant Kt = 15.4 mM. By trans stimulation experiments it could be shown that both D- and L-stereoisomers of hydroxy analogues of branched chain amino acids as well as L-lactate share with the same H+-driven uptake system.
    Notes: Zusammenfassung Hydroxyanaloga essentieller Aminosäuren können ebenso wie ihre Ketoanaloga zur Minimierung der nutritiven Stickstoffaufnahme verwandt werden. In der vorliegenden Arbeit werden Mechanismen der intestinalen Absorption des L-Hydroxyanalogons von Leucin untersucht. Die Aufnahme dieses Substrates in Bürstensaum-Membranvesikel des jejunalen Kaninchendünndarms wird durch einen nach innen gerichteten Protonengradienten stimuliert (pHaußen 6,0; pHinnen 7,5). Die scheinbare Transportkonstante beträgt 15,4mM. Durch das carriervermittelte Transportsystem werden gleichfalls L- und D-Stereoisomere der anderen Hydroxyanaloga verzweigtkettiger Aminosäuren sowie L-Lactat aufgenommen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01610347
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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