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  • 1
    Electronic Resource
    Electronic Resource
    Experience with a Doppler technique to investigate the interaction of isoprenaline and various B-adrenoceptor blocking drugs on blood vessels in the lower limb (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 447-454 
    Details
    ISSN: 1432-1041
    Keywords: Doppler technique ; isoprenaline ; blood velocity ; blood flow ; arterial diameters ; B-adrenoceptor blocking agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A Doppler technique has been used in three separate studies to measure the changes induced by increasing infusion rates of isoprenaline on blood velocity, blood flow and diameters in the femoral and posterior tibial arteries of normal volunteers and to investigate the effects of various B-adrenoceptor antagonists on these changes. Heart rate and blood pressures were also recorded. Isoprenaline produced the expected changes in heart rates and blood pressures in the volunteers and changes induced in these responses by the B-adrenoceptor antagonist were as seen by previous workers. The only expected finding was that systolic blood pressure at the ankle was decreased compared to that in the arm which was increased. Isoprenaline produced reproducible dose-dependant increases in blood velocity, blood flow and diameters in the femoral artery, but little or no effects in the posterior tibial artery. These differences may reflect the difference in distribution of these arteries, the femoral to large muscular beds and the posterior tibial artery essentially to skin vascular beds. The different effects of the B-adrenoceptor blocking drugs with different actions on B1- and B2-adrenoceptors on the responses of the Doppler measurements to isoprenaline would support the differences in distribution of the femoral and posterior tibial arteries and allow a conclusion that the muscle vascular beds contain essentially B2-adrenoceptors with respect to stimulation by isoprenaline. The results obtained in three separate studies using the Doppler technique do suggest that this non-invasive technique may be of value in investigating the physiology, and/or pharmacology of the peripheral circulation in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613460
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Single station and regional analysis of daily rainfall extremes (1989)
    Springer
    Stochastic environmental research and risk assessment 3 (1989), S. 281-292 
    Details
    ISSN: 1436-3259
    Keywords: Generalised Pareto distribution ; Peaks over threshold ; Probability weighted moments ; Regionalisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract A peaks over threshold (POT) method of analysing daily rainfall values is developed using a Poisson process of occurrences and a generalised Pareto distribution (GPD) for the exceedances. The parameters of the GPD are estimated by the method of probability weighted moments (PWM) and a method of combining the individual estimates to define a regional curve is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01543461
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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