ISSN:
1569-8041
Keywords:
BCL-2
;
BCL-6
;
Burkitt lymphoma
;
Burkitt-like lymphoma
;
large B-cell lymphoma
;
non-Hodgkin's lymphoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Introduction:Burkitt-like lymphoma (BLL) is a provisionalcategory of B-cell lymphoma which is morphologically intermediate betweenBurkitt lymphoma (BL) and large B-cell lymphoma (LBCL). The clinicalsignificance of this morphology is controversial. Patients and methods:We examined 41 cases of pediatric B-celllymphoma by immunohistochemistry for proteins associated with proto-oncogenesc-myc, BCL-2and BCL-6and a subset of cases (withadequate slides) for a proliferation-associated marker (Ki-67) and forapoptosis (Apop-Tag). Sixteen cases of BLL, thirteen cases of BL and twelvecases of LBCL were examined. Results:Our results showed BCL-6expression in 16 of 16BLL, 4 of 13 BL, and 9 of 12 LBCL; c-mycexpression in 14 of 15 BLL,9 of 13 BL, and 12 of 12 LBCL; and BCL-2expression in 2 of 16 BLL,0 of 13 BL, and 6 of 12 LBCL. Mean apoptotic index for BLL was 10.3%(n = 6); for BL was 17.1% (n = 5); and for LBCL was10.9% (n = 6). Ki-67 was diffusely reactive in all casestested. There was a significantly higher proportion of BLL than BL whichexpressed BCL-6(P = 0.0001). Conclusions:Labeling for BCL-6distinguishes BLL fromBL. It is likely that in children in North America, BLL is biologicallydistinct from BL and more closely resembles a subset of LBCL.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008340819790
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