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  • 1
    Electronic Resource
    Electronic Resource
    Changes in the haemolytic activity of serum complement during acuteBabesia bovis infection in cattle (1980)
    Springer
    Parasitology research 62 (1980), S. 39-45 
    Details
    ISSN: 1432-1955
    Keywords: Babesia bovis ; Complement ; Immunity ; Cattle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The haemolytic activity of serum complement was measured in cattle during acuteBabesia bovis infection. The level fell significantly on day 5 post infection (p.i.) and was not detectable by day 10 p.i. After clinical recovery between days 15 and 20 p.i. haemolytic activity was again detected in serum and gradually returned to the pre-infection level. The components of both classical and alternative pathways were involved in complement depletion and factors such as protease secretion by the parasites, antigenantibody reactions, and the release of haemoglobin were implicated as causes of the decline. The absence of complement activity during the acute phase of the disease may interfere with immune mechanisms at a critical time for the host.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00925365
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The irradiation ofBabesia bovis (1980)
    Springer
    Parasitology research 63 (1980), S. 47-57 
    Details
    ISSN: 1432-1955
    Keywords: Babesia ; Irradiation ; Virulence ; Pathogenicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Babesia bovis parasites attenuated by 35 krads γ irradiation and parasites not exposed to irradiation, were injected into intact 2-year-old Hereford steers. All five animals receiving non-irradiated blood died but the five animals which received irradiated blood were only mildly affected. Highly significant differences were observed in changes to plasma fibrinogen, serum fibrinogen-like proteins, packed cell volume, partial thromboplastin time, prothrombin time, blood kinins, and plasma kininogen levels in the control animals but non-significant changes in these parameters occurred in the group receiving irradiated blood. Significant changes in the antiplasmin, α2M, and the antithrombin levels occurred in control cattle but not in the group receiving irradiated blood. Parasite multiplication rates and maximum parasitaemias were similar in both groups. Irradiation reduced the dose of living parasites from 1×108 to 2.5×103, but this was not the reason for the mild reactions. It was concluded that irradiation had selected an avirulent parasite population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00927725
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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