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  • Baby blues  (1)
  • Synaptosomes  (1)
  • Type A monoamine oxidase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Postnatal depression – myth and reality: maternal depression before and after the birth of a child (2000)
    Springer
    Social psychiatry and psychiatric epidemiology 35 (2000), S. 19-27 
    Details
    ISSN: 1433-9285
    Keywords: Key words Postnatal depression ; Baby blues ; Longitudinal survey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Background: Much has been written about postnatal depression as a clinical condition. There is some evidence to suggest that a substantial proportion of women who give birth experience a depression in the postnatal period. This paper reports the results of a longitudinal study of the mental health of a large sample of women who were in the early stages of pregnancy at entry to the study. Methods: Each participant was assessed for symptoms of depression at the first clinic visit (entry to the study), and reassessed at various intervals – at 3–5 days, at 6 months, and again at 5 years after the birth of the child – using the DSSI-D (Delusions-Symptoms-States Inventory). Results: Retrospective recall questions indicate that shortly after the birth the majority of women experienced some depressed mood. Of those who experienced depressed mood, the data suggest that the symptoms were not severe, nor did these symptoms generally continue beyond a few weeks. The longitudinal data indicate that levels of depression in our sample are highest either at the first clinic visit or at the 5-year follow-up. Rates of depression at the 6-month follow-up are relatively low by comparison. Conclusion: While most mothers experience periods of depressed mood after the birth of their baby, these periods are generally of short duration and of lesser intensity than a major depression. Mothers appear to experience increasing levels of symptoms of depression as their child grows up. Many of the “cases” of depression experienced at the 5-year follow-up represent a recurrence of a previous experience of depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001270050004
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of selective type A or type B monoamine oxidase inhibition on the intrasynaptosomal deamination of (3H)serotonin in rat spinal cord tissue (1988)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 338 (1988), S. 9-13 
    Details
    ISSN: 1432-1912
    Keywords: Serotonin metabolism ; Synaptosomes ; Type A monoamine oxidase ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The degree to which the type A and type B forms of monoamine oxidase participate in the intraneuronal deamination of (3H)serotonin (5-HT) was examined in synaptosomal-rich fractions of rat spinal cord tissue. Synaptosomes were labeled with (3H)5-HT and superfused with physiological buffers containing selective concentrations of a type A (clorgyline) or a type B (deprenyl) MAO inhibitor. The efflux of (3H)5-HT and newly-formed (3H)5-hydroxyindoleacetic acid (5-HIAA) was determined and compared to controls over time. In control samples, a slight decline in (3H)5-HT efflux occurred over the experimental superfusion period. However, a stable formation and efflux of (3H)5-HIAA was seen during this same period of time. When clorgyline was added to the superfusion buffer, a rapid decline in superfusate levels of (3H)5-HIAA was observed. Similar experiments in the presence of deprenyl were without effect. In order to elevate cytoplasmic concentrations of (3H)5-HT and therefore increase its chances for interaction with nerve terminal MAO, reserpine was added to the superfusion buffer. Reserpine caused a greater than 3-fold increase in (3H)5-HIAA formation with no change in (3H)5-HT efflux. Clorgyline inhibited this increase in (3H)5-HIAA formation but deprenyl was again without effect. In the presence of clorgyline, reserpine also caused an increase in (3H)5-HT efflux. These results strongly support the notion that 5-HT deamination within rat spinal cord nerve terminals occurs primarily, if not exclusively, through an interaction with type A MAO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168805
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    Paper (German National Licenses)
    Fulltext
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