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  • 1
    ISSN: 1432-2072
    Keywords: Ethanol withdrawal ; Hyperexcitibility GABAB receptors ; Baclofen ; CGP 35348
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the GABAB agonist baclofen and the GABAB antagonist CGP35348 were examined on the behavioural hyperexcitability which is seen on cessation of chronic ethanol treatment. When baclofen was given to mice of the TO strain after withdrawal from ethanol inhalation, there was evidence of increased hyperexcitability with one dose, 2.5 mg/kg, but no significant change was seen with other doses, 1.25 and 10 mg/kg. When given after withdrawal from a liquid diet containing ethanol, baclofen, 10 mg/kg, produced a large, but short lasting, increase in the ratings of hyperexcitability during the withdrawal period. This effect was significantly decreased when the antagonist CGP35348, 300 mg/kg, was given with baclofen 10 mg/kg. When the antagonist was given alone at 300 mg/kg it significantly decreased the hyperexcitability during ethanol withdrawal. Increases in the ratings of hyperexcitability were seen when baclofen was given to control mice, which had not received ethanol, and these effects were significant, so the effects during ethanol withdrawal were not confined to that syndrome. CGP35348 decreased the behavioural ratings in control animals, and blocked the effects of baclofen 10 mg/kg. When the effects of the compounds on spontaneous locomotor activity in control mice were measured, this parameter was decreased both by baclofen and by CGP35348, at does which were effective in altering the handling-induced behaviour.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5060
    Keywords: Brassica spp. ; cabbage root fly ; Delia radicum ; host plant resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Wild Brassica species and associated breeding lines were evaluated for their resistance to Delia radicum, the cabbage root fly, in the field in 1993 and in the field, glasshouse and laboratory in 1996. High levels of antibiosis resistance were discovered in the field in 1993 in Brassica fruticulosa, B. incana, B. villosa and B. spinescens and confirmed in the field in 1996 while two B. oleracea accessions and the susceptible control Brussels sprouts variety, ‘Oliver’, were highly susceptible. No D. radicum pupae were found in the soil around the roots of B. fruticulosa and B. spinescens at the end of the season. All the Brassica species were attractive to egg-laying by D. radicum in the field and in a laboratory experiment and therefore lacked antixenosis resistance. In a series of glasshouse experiments, Brassica species and breeding lines were inoculated with D. radicum eggs supplied from a laboratory culture and the effects of larval feeding on plants recorded. Brassica incana, B. fruticulosa and B. spinescens were highly resistant, most plants surviving, whilst B. macrocarpa and B. villosa were moderately resistant as were two F1 lines bred from a cross between B. macrocarpa and B. oleracea.
    Type of Medium: Electronic Resource
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