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  • 1
    ISSN: 1615-2573
    Keywords: Stent ; Balloon dilatation ; Pulmonary artery stenosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was performed to determine the efficacy of balloon-expandable stents in the treatment of branch pulmonary artery-stenoses and conduit stenosis in children. A total of eight stainless steel stents were implanted in seven patients. Three patients had tetralogy of Fallot with pulmonary artery stenosis following total correction, one patient had conduit stenosis following correction of transposition of the great arteries, one patient had intra-cardiac conduit stenosis after septation for single left ventricle, and two patients had pulmonary artery stenosis after Fontan operation. Six stents were placed in the branch pulmonary arteries, one in the extracardiac conduit, and one in the intracardiac conduit. The mean age at implantation was 13 ± 3 years and the mean weight 37 ± 12kg. Follow-up time ranged from 0.3–2 years. The diameter of pulmonary arteries with stenoses increased from 5.6 ± 2.2 mm to 10.6 ± 1.8 mm (n = 7). The systolic pressure gradient decreased from 56 ± 26 mmHg to 22 ± 16 mmHg (n = 5). No embolization or thrombotic event has been noted. One stent placed in the intracardiac conduit was compressed and fractured. These data indicate that balloon-expandable stents are useful in the treatment of pulmonary artery branch stenoses and extracardiac conduit stenosis in children. The use of stents for intracardiac stenosis may result in stent fracture.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1860-1499
    Keywords: Immunoelectron microscopy ; Dilated cardiomyopathy ; Immunocytochemistry ; Desmin filament
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Desmin filaments specific for muscle cells, normally localized at the Z band level and intercalated discs, may play an important role in maintaining the structure of the cardiomyocytes. By immunoelectron microscopy, we examined the distribution of desmin in endomyocardial biopsy samples of 10 patients with dilated cardiomyopathy. We found an increased number of desmin filaments characterized by a disordered arrangement in the myocytes. Desmin immunolabeling was transversely and longitudinally distributed at the Z band level and near the intercalated discs within the cytoplasm of the myocytes lacking myofilaments. These data suggest that desmin filaments could play a role in the defence mechanisms of the cardiomyocytes threatened by stress overloading in the diseased human heart.
    Type of Medium: Electronic Resource
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