ISSN:
1612-1112
Keywords:
Barbiturates
;
Reversed-phase TLC
;
RF-structure correlations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Twenty barbituric acid derivatives having four different types of substitution were separated in TLC-S chambers. Using non-polar adsorbents (silanized silica gel or silica gel coated with paraffin oil) and binary water-organic solvent mixtures as the mobile phase. Linear relationships between RM and the concentration of the organic solvent were observed for the majority of the investigated compounds. The non-polar absorbents ensure a better separation than untreated silica gel especially for the therapeutically useful C5 disubstituted barbiturates. The results can be used for the optimization of the systems for the chromatography of barbiturates. The Rf values were correlated with the number of carbon atoms of the substitutions, molecular connectivity and a parameter associated with the molecular volume. The best correlations were obtained for this last parameter.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02261617
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