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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 328 (1985), S. 351-353 
    ISSN: 1432-1912
    Keywords: Bay K 8644 ; Insulin secretion ; Mouse pancreatic islets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the dihydropyridine derivative Bay K 8644 upon insulin secretion by perifused isolated mouse pancreatic islets were examined. At a non-stimulatory glucose concentration (5 mmol/l) Bay K 8644 (1 μmol/l) did not stimulate insulin release. However, the same drug concentration enhanced the insulin secretory responses to an intermediate (15 mmol/l) or high (30 mmol/l) glucose concentration by 80 or 90%, respectively. Bay K 8644 was half maximally effective at 0.1 μmol/l and maximally effective at 1 μmol/l. The results are compatible with the view that voltage-dependent calcium channels are essential for stimulus-secretion coupling in pancreatic B-cells.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2584
    Keywords: Bladder tumor ; Renal cell carcinoma ; Transitional cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of a 61-year-old man, with a rare combination of two advanced urological tumors: a concomitant spread of an adenocarcinomabeyond the kidney and a urothelial carcinoma beyond the bladder. Wesimultaneously performed a primary curative prostatovesiculectomy anda nephroureterectomy on the right with ileal neobladder. To ourknowledge, a case report of concomitant spread of an adenocarcinomabeyond the kidney (pT3 pN0 M0 G3) and a urothelial carcinoma beyondthe bladder (pT3a pN0 M0 G3) with subsequent curative therapy hasthus far not been published. A combination of the two diseasesdescribed here is obviously a remarkable rarity.
    Type of Medium: Electronic Resource
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