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  • Bay m 1099  (1)
  • Type 2 (non-insulin-dependent) diabetes  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Hypomagnesaemia in Type 2 (non-insulin-dependent) diabetes mellitus is not corrected by improvement of long-term metabolic control (1992)
    Springer
    Diabetologia 35 (1992), S. 77-79 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; Type 2 (non-insulin-dependent) diabetes ; insulin resistance ; magnesium ; electrolytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Low levels of magnesium have frequently been reported in diabetes mellitus especially in poorly controlled Type 1 (insulin-dependent) diabetic patients. Furthermore hypomagnesaemia might contribute to insulin resistance in Type 2 (non-insulin-dependent) diabetes. As the influence of improved metabolic control on plasma magnesium levels is unknown in Type 2 diabetic patients we studied magnesium plasma levels in 50 patients 1) before, 2) one and 3) three months after the initiation of insulin therapy or intensified treatment with oral hypoglycaemic agents. Magnesium plasma levels were measured by a colorimetric method and were significantly reduced in diabetic patients compared to healthy control subjects (0.79±0.01 mmol/l vs 0.88±0.01 mmol/l; p〈0.0001). Metabolic control was significantly improved as documented by reduced HbA1C levels in both insulin-treated patients or the patients on oral hypoglycaemic agents (p〈0.003). However, plasma magnesium levels remained unchanged during the follow-up in the insulin-treated group (1∶0.79±0.02 mmol/l; 2∶0.81±0.02 mmol/l; 3∶0.79±0.01 mmol/l) as well as in the patients on oral hypoglycaemic agents (1∶0.79±0.03 mmol/l; 2∶0.78±0.02 mmol/ l; 3∶0.84±0.04 mmol/l). This study shows that even marked improvement of glycaemic control does not correct hypomagnesaemia in Type 2 diabetes. We conclude that hypomagnesaemia might be related to the insulin-resistant state and that possible beneficial effect of chronic magnesium administration should be evaluated in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400855
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of theα-glucosidase inhibitor 1 desoxynojirimycin (BAY M 1099) on postprandial blood glucose, serum insulin and C-peptide levels in type II diabetic patients (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 417-419 
    Details
    ISSN: 1432-1041
    Keywords: diabetes mellitus ; Bay m 1099 ; Type II diabetic patients ; desoxynojirimycin ; alpha-glucosidase inhibitor ; metabolic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Bay m 1099 is a newly developed inhibitor of intestinalα-glucosidase. Its ability to lower postprandial plasma glucose, serum insulin and C-peptide levels in Type II diabetics has been investigated. Fifteen obese Type II diabetic patients with inadequate metabolic control during sulphonylurea treatment received a standardized diet and were treated either with Bay m 1099, b.d. (100 mg before breakfast and dinner) or placebo for 3 days, according to a double-blind cross-over design. The postprandial blood glucose level was significantly lower during Bay m 1099 treatment compared to placebo after breakfast and dinner (AUC after breakfastp〈0.001). The reduced postprandial hyperglycaemia was associated with a decrease in meal stimulated serum insulin and C-peptide levels. Thus, Bay m 1099 may be a useful addition in the treatment of Type II diabetic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607953
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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