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  • 1
    Electronic Resource
    Electronic Resource
    Involvement of signal transduction pathways in Salmonella typhimurium porin activated gut macrophages (1999)
    Springer
    Molecular and cellular biochemistry 194 (1999), S. 235-243 
    Details
    ISSN: 1573-4919
    Keywords: S. typhimurium ; porins ; macrophages ; protein kinase C ; nitric acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Many membrane proteins are implicated in the regulation of cell functions by triggering specific signaling pathways. Porins are known potential modulators of cell proliferation and differentiation. We explored the possible involvement of this protein in signal transduction pathways in mouse gut macrophages. In the present work we have shown that porins can trigger signal transduction in mouse macrophages infected with S. typhimurium. Activation of macrophages by porins results in an increase in inositol trisphosphate and intracellular Ca2+ mobilization. There is a translocation of protein kinase C to the membrane which is accompanied by nitric oxide release within the macrophages. This effect is the outcome of the expression of nitric oxide synthase, which is dependent on Protein kinase C. Further, we observed that there is an increased binding of the porins on macrophages infected with S. typhimurium which results in activation of macrophages and triggering of specific signaling pathways. These results indicate that porins induce the production of nitric oxide via a protein kinase C dependent pathway. Nitric oxide plays a fundamental role in macrophage effector function where it has both communication and defensive function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006971621653
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    P-glycoprotein (MDR 1 gene product) in cells of the immune system: Its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection (1993)
    Springer
    Journal of clinical immunology 13 (1993), S. 289-301 
    Details
    ISSN: 1573-2592
    Keywords: Multidrug resistance ; T cells ; B cells ; macrophages ; natural killer cells ; cytotoxicity ; aging ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract P-glycoprotein, a 170-kd glycoprotein encoded by theMDR 1 gene, is a member of a highly conserved superfamily of ATP-binding cassette (ABC) transport proteins. It shares extensive homology with numerous bacterial and eukaryotic ABC transport proteins. P-glycoprotein acts as an energy-dependent efflux pump that appears to transport structurally diverse agents ranging from ions to peptides. P-glycoprotein (P-gP) has been implicated as playing a role in multidrug (MDR) resistance in cancer, chloroquine-resistantPlasmodium falciparum infection, and possibly human immunodeficiency virus-1 (HIV-1) resistance to nucleoside compounds. A number of normal tissues in humans and rodents have been shown to express high levels of P-gp. The expression and function of P-gp in cells of the immune system have been explored in the past 2 years. This review presents a state of the art regarding the expression, regulation, and function of Pgp in cells of the immune system. In addition, its alteration in aging and HIV-1 infection is reviewed. A possible physiologic role of P-gp in cytokine secretion, antigen processing/presentation, and effector functions is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00920237
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cartilage-Hair Hypoplasia Syndrome: Increased Apoptosis of T Lymphocytes Is Associated with Altered Expression of Fas (CD95), FasL (CD95L), IAP, Bax, and Bcl2 (1999)
    Springer
    Journal of clinical immunology 19 (1999), S. 428-434 
    Details
    ISSN: 1573-2592
    Keywords: Cartilage-hair hypoplasia ; T cell subsets ; cytokines ; Fas ; FasL ; Bcl-2 ; Bax
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cartilage-hair hypoplasia (CHH) is a rare autosomal recessive short-limbed dwarfism associated with thin and sparse hair and cell mediated or combined immunodeficiency. However, the basis of immune deficiency in CHH is unclear. In this study, we investigated a role of apoptosis in immunodeficiency in a patient with CHH. An increased apoptosis of both CD4+ and CD8+ T cells, as determined by TUNEL assay, was observed in CHH compared to an age-matched healthy dwarf control. Increased apoptosis in CHH was associated with increased expression of Fas (CD95), CD95L, and Bax and decreased expression of Bcl-2 and inhibitor of apoptosis protein (IAP) compared to the control. These data suggest that lymphopenia and immunodeficiency in CHH may be, at least in part, due to increased apoptosis of T cells, possibly through the Fas/ FasL signaling pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020563018864
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Programmed Cell Death (Apoptosis) in Cord Blood Lymphocytes (1997)
    Springer
    Journal of clinical immunology 17 (1997), S. 63-73 
    Details
    ISSN: 1573-2592
    Keywords: Cord blood ; apoptosis ; Fas ; Bcl-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cord blood lymphocytes are functionally immature and have deficient immune responses. In order to determine whether the process of programmed cell death is distinct between cord blood and peripheral blood lymphocytes, we analyzed the expression of fas and bax (apoptosis promoting genes) and bcl-2 and bcl-x L (apoptosis inhibiting genes) at protein or mRNA levels using flow cytometry and quantitative PCR methods, respectively. The susceptibility of T cell subsets from cord blood and adult peripheral blood to undergo apoptosis following restimulation with anti-CD3 or anti-Fas monoclonal antibodies was also studied. We observed that cord blood T cell subsets expressed lower levels of Fas and Bcl-2, a low bcl-2/bax ratio, and higher bcl-x L compared to peripheral blood. Additionally, upon primary stimulation with anti-CD3, cord blood T cell subsets were more resistant to apoptosis compared to peripheral blood. In contrast, rechallenge of previously stimulated lymphocytes with anti-CD3 monoclonal antibody triggered apoptosis in a larger proportion of T cells from cord blood as compared to peripheral blood, whereas the number of T cells undergoing anti-Fas-induced programmed cell death were lower in cord blood compared to peripheral blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027340529644
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    Paper (German National Licenses)
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