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  • Beaufort Sea Mackenzie Delta Thermokarst lake Embayment Arctic Cesium radiocarbon Geochemistry Permafrost Acoustic stratigraphy  (1)
  • Cell & Developmental Biology  (1)
  • immunotherapy  (1)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Characterisation of marine and lacustrine sediments in a drowned thermokarst embayment, Richards Island, Beaufort Sea, Canada (2000)
    Springer
    International journal of earth sciences 89 (2000), S. 503-521 
    Details
    ISSN: 1437-3262
    Keywords: Beaufort Sea Mackenzie Delta Thermokarst lake Embayment Arctic Cesium radiocarbon Geochemistry Permafrost Acoustic stratigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract. A multidisciplinary study was made of lakes and lagoons in a thermokarst embayment on Richards Island, Canadian Beaufort Sea, in order to investigate the response of the Mackenzie Delta shoreline to changing hydrological influences. Seismo-acoustic profiles made from an amphibious vehicle, combined with sediment core data, show that the deepest lakes contain up to 10 m of transparent or stratified silty mud overlying the Kittigazuit sand basement. Palynological and microfossil data from 21 surface samples allow delineation of freshwater, saltmarsh, tidal flat and subtidal assemblages. These modern reference data allow distinction of freshwater and marine facies in the cores and subsequent interpretation of geochemical content (carbon, ammonia, sulphate). Radiocarbon dates and 137 Cs show that sedimentation rates have increased by an order of magnitude since drowning of the embayment during the past millennium, and that most of this sediment is from the Mackenzie River plume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005310000126
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    New Non-cytotoxic Approaches to Ovarian Cancer (1999)
    Springer
    Annals of oncology 10 (1999), S. 65-68 
    Details
    ISSN: 1569-8041
    Keywords: drug resistance ; genetic therapy ; immunotherapy ; metalloproteinase inhibitors ; radioconjugates ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two recent examples of conventional cytotoxic drugs, taxoids and topo I inhibitors, are set to make a real impact in the treatment of ovarian cancer. However, further progress may depend on novel approaches, focusing on other targets. This review will concentrate on those approaches which have already led to the initiation of clinical trials: agents designed to circumvent cellular drug resistance, signal transduction inhibitors, new hormonal agents, matrix metalloproteinase inhibitors, immunotherapy, immunotoxins and radioconjugates, and intraperitoneal genetic therapy, including the use of replicating viruses. In some cases, early clinical data are encouraging, but ultimately combined treatment with conventional agents may make most impact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008315603401
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Electron microbeam analysis of calcium distribution in the ciliated protozoan, Spirostomum ambiguum (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 91 (1977), S. 409-416 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Electron microprobe analyses of calcium distribution in the ciliated protozoan, Spirostomum ambiguum, indicated several calcium rich sites. One site was an endoplasmic distribution of calcium coincident with phosphorus which corroborates previous findings of hydroxyapatite deposits within Spirostomum. These apatite deposits were distributed throughout the endoplasm, but not within the nuclei or the contractile vacuole. Calcium was also detected within the cortical region. Cortical calcium was in greater concentration in the anterior portion of the organism and decreased towards the posterior end (region containing the contractile vacuole). Phosphorus and potassium were also detected as gradients from the anterior end, whereas magnesium was detected in the same density throughout the cortical region. Line scans of cortical regions suggested (1) distributions of calcium within mitochondria and/or vesicles, and (2) calcium associated with bundles of microfilaments.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040910311
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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