Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Beaufort Sea Mackenzie Delta Thermokarst lake Embayment Arctic Cesium radiocarbon Geochemistry Permafrost Acoustic stratigraphy  (1)
  • experimental mod  (1)
  • immunotherapy  (1)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    New Non-cytotoxic Approaches to Ovarian Cancer (1999)
    Springer
    Annals of oncology 10 (1999), S. 65-68 
    Details
    ISSN: 1569-8041
    Keywords: drug resistance ; genetic therapy ; immunotherapy ; metalloproteinase inhibitors ; radioconjugates ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two recent examples of conventional cytotoxic drugs, taxoids and topo I inhibitors, are set to make a real impact in the treatment of ovarian cancer. However, further progress may depend on novel approaches, focusing on other targets. This review will concentrate on those approaches which have already led to the initiation of clinical trials: agents designed to circumvent cellular drug resistance, signal transduction inhibitors, new hormonal agents, matrix metalloproteinase inhibitors, immunotherapy, immunotoxins and radioconjugates, and intraperitoneal genetic therapy, including the use of replicating viruses. In some cases, early clinical data are encouraging, but ultimately combined treatment with conventional agents may make most impact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008315603401
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Basic Research: How Much do we Know, and What are we Likely to Learn About Ovarian Cancer in the Near Future? (1999)
    Springer
    Annals of oncology 10 (1999), S. 69-73 
    Details
    ISSN: 1569-8041
    Keywords: BRCA1 ; experimental mod ; ovarian tumours ; ROSE ; suppressor genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The scientific community, which studies ovarian cancer in the laboratory, is making progress in understanding many aspects of the disease. At present there is evidence that the cancer prone ovary has a preneoplastic phenotype. These genetic changes may constitute a surrogate intermediate end-point biomarker of cancer risk, which might be altered by preventive measures. Studies that aim at understanding the genetic basis of the disease are reviewed. Many of these studies use clinical ovarian cancer samples. To augment study of clinical specimens, an experimental system has been developed where malignancy is induced in the rat ovarian surface epithelium (ROSE). This system markedly facilitates examination of how genes fit into the ovarian cancer puzzle. The problem of drug resistance in ovarian cancer has received considerable attention. Although the functional changes responsible for resistance have been identified there has been little progress in identifying the actual g enes capable of conferring the substantial resistance seen in cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008367620240
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Characterisation of marine and lacustrine sediments in a drowned thermokarst embayment, Richards Island, Beaufort Sea, Canada (2000)
    Springer
    International journal of earth sciences 89 (2000), S. 503-521 
    Details
    ISSN: 1437-3262
    Keywords: Beaufort Sea Mackenzie Delta Thermokarst lake Embayment Arctic Cesium radiocarbon Geochemistry Permafrost Acoustic stratigraphy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract. A multidisciplinary study was made of lakes and lagoons in a thermokarst embayment on Richards Island, Canadian Beaufort Sea, in order to investigate the response of the Mackenzie Delta shoreline to changing hydrological influences. Seismo-acoustic profiles made from an amphibious vehicle, combined with sediment core data, show that the deepest lakes contain up to 10 m of transparent or stratified silty mud overlying the Kittigazuit sand basement. Palynological and microfossil data from 21 surface samples allow delineation of freshwater, saltmarsh, tidal flat and subtidal assemblages. These modern reference data allow distinction of freshwater and marine facies in the cores and subsequent interpretation of geochemical content (carbon, ammonia, sulphate). Radiocarbon dates and 137 Cs show that sedimentation rates have increased by an order of magnitude since drowning of the embayment during the past millennium, and that most of this sediment is from the Mackenzie River plume.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005310000126
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...