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  • 1
    Digitale Medien
    Digitale Medien
    Developmental changes in pharmacological responsivity of the acoustic startle reflex: Effects of picrotoxin (1983)
    Springer
    Psychopharmacology 79 (1983), S. 87-93 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Acoustic startle reflex ; Picrotoxin ; Ontogeny ; GABA ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Using the acoustic startle reflex as the behavioral measure, qualitatively different responses to the GABA antagonist picrotoxin were obtained in developing rats before and after 21 days postnatal (PN) age. Dose-dependent increases in acoustic startle were seen following picrotoxin in PN day 15–16 rat pups. In contrast, dose-dependent decreases in startle following picrotoxin were observed in adult rats. The switch from excitation to inhibition of startle was found to occur abruptly on PN day 21. Excitatory responses to picrotoxin were also found in adult rats following localized infusions of picrotoxin into lumbar spinal cord regions, but not into the forebrain. These results give evidence that picrotoxin-sensitive sites that modulate increases in startle reflex behavior mature first and are analogous to sites in the adult spinal cord, whereas picrotoxin-sensitive sites that modulate decreases in startle reflex behavior mature later (≥PN day 21) and are localized in more rostral brain areas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00427790
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function (1993)
    Springer
    Psychopharmacology 112 (1993), S. S60 
    Details
    ISSN: 1432-2072
    Schlagwort(e): 5-Hydroxytryptamine2 (5-HT2) receptors ; 5-Hydroxytryptamine3 (5-HT3) receptors ; Dopamine ; Substantia nigra ; Ventral tegmental area ; Nucleus accumbens ; Striatum ; Behavior ; Amphetamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Several lines of evidence have suggested a link between serotonergic and dopaminergic systems in the brain. The interpretation of much of these early data needs careful reevaluation in light of the recent understanding of the plethora of serotonin receptor subtypes, their distribution in the brain and the new findings with more selective serotonin antagonists. Electrophysiological, biochemical and behavioral evidence obtained using highly selective antagonists of the 5-HT2 or 5-HT3 receptor subtypes, MDL 100,907 or MDL 73,147EF, respectively, supports the thesis that serotonin modulates the dopaminergic system. This modulation is most evident when the dopaminergic system has been activated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02245008
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