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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 349 (1979), S. 582-583 
    ISSN: 1435-2451
    Keywords: Liver tumors ; Oral contraceptives ; Diagnosis ; Therapy ; Benigne Lebertumoren ; Kontrazeption ; Diagnose ; Therapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vom 1.1.1976–1.10.1978 wurden 8 Frauen, die jahrelang Kontrazeptiva eingenommen hatten, mit gutartigen Lebertumoren behandelt, in allen Fällen lautete die histologische Diagnose: fokale noduläre Hyperplasie. Bei 6 Patientinnen war der Tumor uni-, bei 2 bilokulär. Als diagnostische Verfahren bewährten sich in der Reihenfolge Computertomo-, Sono-, Szinti-und Angiographie. Eine Artdiagnose war nur mit der Laparoskopie und Biopsie aus dem Tumor und dem gesunden Lebergewebe möglich. - Da diese Tumoren bluten und selten maligne entarten können, wurden sie durch Enucleation oder Resektion entfernt. Zwei auf den Lebervenen lokalisierte Zweittumoren wurden belassen. Die Letalität betrug 0 %. Nach 1-2jähriger Beobachtungszeit haben sich die belassenen Geschwülste nach Absetzen der Kontrazeptiva nicht verkleinert. Die chirurgische Entfernung dieser Tumoren wird wegen ihrer Persistenz und ihrer Komplikationsmöglichkeiten als Behandlungsverfahren der Wahl empfohlen.
    Notes: Summary From 1.1. 1976-1.10.1978 8 women taking oral contraceptives for many years were admitted with benign hepatic tumors. The histological diagnosis in all cases was focal nodular hyperplasia. In 6 women the tumor was single, in 2 women multicentric. Diagnosis by computer tomography, sonography, liver scanning and angiography. A specific diagnosis is only possible by laparoscopy with biopsy of the tumour and the normal liver tissue. Because of the danger of rupture and intra-abdominal hemorrhage and a rare trend to malignancy, enucleation or resection of these tumours was performed; two of the multicentric hepatomas localized at the hepatic veins remained in place. Mortality was 0 %. After cessation of oral contraceptives the remaining tumors did not change in size during one to two years. Enucleation or resection is recommended treatment of choice for benign hepatic tumors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 322-327 
    ISSN: 0935-6304
    Keywords: Preparative capillary GC ; Multidimensional GC ; Capillary techniques ; Enrichment ; Trace analysis ; Thermal desorption ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An automated system for preparative gas chromatography with capillary columns is described. The effluet from the capillary column is switched to the FID detector or to the traps by means of a Live-T switching device. The pneumatics is controlled by a microprocessor so that repetitive sampling can be performed over a period of days in order to enrich sufficient amount of material for NMR or other spectroscopic methods. The effluent containing the compounds is collected in glass tubes filled with column packing material (e.g. Chromosorb coated with 3% OV - 101, crosslinked). The trap temperatue can be adjusted from + 20°C to - 80°C, depending on the trapping material and volatility of trapped substances. The analysis of enriched substances or chromatographic fractions can be performed by thermal desorption of the same traps or by solven elution. The recovery of enriched substances is higher than 90%. High capacity and resolution for enrichment of trace components are obtained with the aid of a double column-double oven system. Examples of such applications are given.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 340 (1998), S. 683-685 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A procedure for the quantification of double-strand breaks in yeast is presented that utilizes pulsed field gel electrophoresis (PFGE) and a comparison of the observed DNA mass distribution in the gel lanes with calculated distributions. Calculation of profiles is performed as follows. If double-strand breaks are produced by sparsely ionizing radiation, one can assume that they are distributed randomly in the genome, and the resulting DNA mass distribution in molecular length can be predicted by means of a random breakage model. The input data for the computation of molecular length profiles are the breakage frequency per unit length, α, as adjustable parameter, and the molecular lengths of the intact chromosomes. The obtained DNA mass distributions in molecular length must then be transformed into distributions of DNA mass in migration distance. This requires a calibration of molecular length vs. migration distance that is specific for the gel lane in question. The computed profiles are then folded with a Lorentz distribution with adjusted spread parameter Γ to account for and broadening. The DNA profiles are calculated for different breakage frequencies α and for different values of Γ, and the parameters resulting in the best fit of the calculated to the observed profile are determined.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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