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  • Benzodiazepines  (1)
  • Chemical Engineering  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A new method for the evaluation of benzodiazepines based on their ability to block muscimol-induced myoclonic jerks in mice (1981)
    Springer
    Psychopharmacology 75 (1981), S. 291-293 
    Details
    ISSN: 1432-2072
    Keywords: Muscimol ; Benzodiazepines ; Myoclonic jerks ; Animal model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A number of clinically used benzodiazepines were tested for their effectiveness in blocking muscimol-induced myoclonic jerks in mice. Their ED50 values were determined from their dose-response curves. These data gave the following relative potencies with respect to diazepam: diazepam=1, medazepam=0.24, oxazepam=1.27, flurazepam=1.90, lorazepam=3.01, nitrazepam=3.93, clonazepam=33.14, and flunitrazepam=116.00. Because our earlier studies indicated that muscimol-induced myoclonic jerks probably originate from the spinal cord, the present method may prove to be suitable for quantitatively evaluating the effect of benzodiazepines on the spinal cord. The present results also indicate the possible value of flunitrazepam in the management of neurologic disorders in which preferential action on the spinal cord is desired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432441
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Separation of fine particle dispersions using periodic flows in a spining coiled tube (1986)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 32 (1986), S. 798-808 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A centrifugal method for fractionating fine (〈10 μm) particles by size and/or density is described. Periodic, bidirectional flow through a continuously spinning coiled tube splits fine particle suspensions into two fractions. Proof-of-principle experiments with zeolite powder have demonstrated successful concentration of aqueous dispersions.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690320510
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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