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  • Benzodiazepines  (2)
  • Occupational Health and Environmental Toxicology  (2)
  • [abr] ATEE; acetyltyrosine ethyl ester  (2)
  • [abr] DFP; di-isopropylphosphofluridate  (2)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Serine proteinase activation of latent human skin collagenase
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 125 (1984), S. 279-285 
    Details
    ISSN: 0006-291X
    Keywords: [abr] ATEE; acetyltyrosine ethyl ester ; [abr] DFP; di-isopropylphosphofluridate ; [abr] HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid ; [abr] PMSF; phenylmethanesulphonylfluoride ; [abr] RDEB; recessive dystrophic epidermolysis bullosa ; [abr] SBTI; soya bean trypsin inhibitor ; [abr] TAME; tosylarginine methyl ester ; [abr] TLCK; tosyllysine chloromethylketone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(84)80365-4
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Serine proteinase activation of latent human skin collagenase
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 125 (1984), S. 279-285 
    Details
    ISSN: 0006-291X
    Keywords: [abr] ATEE; acetyltyrosine ethyl ester ; [abr] DFP; di-isopropylphosphofluridate ; [abr] HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid ; [abr] PMSF; phenylmethanesulphonylfluoride ; [abr] RDEB; recessive dystrophic epidermolysis bullosa ; [abr] SBTI; soya bean trypsin inhibitor ; [abr] TAME; tosylarginine methyl ester ; [abr] TLCK; tosyllysine chloromethylketone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(84)80365-4
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Benzodiazepines and caffeine: effect on daytime sleepiness, performance, and mood (1990)
    Springer
    Psychopharmacology 101 (1990), S. 160-167 
    Details
    ISSN: 1432-2072
    Keywords: Humans ; Benzodiazepines ; Caffeine ; Sleepiness ; Performance ; Mood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a double-blind parallel group design, 80 young adult males were divided into eight treatment groups. Subjects received 15 or 30 mg flurazepam, 0.25 or 0.50 mg triazolam, or placebo at bedtime, and 250 mg caffeine or placebo in the morning for 2 treatment days. Two objective (Multiple Sleep Latency Test and lapses) and two subjective (Stanford Sleepiness Scale and Visual Analog Scale) measures of sleepiness, five performance tests, and two mood measures (Profile of Mood Scale and Visual Analog Mood Scale) were administered repeatedly on both days. Significant treatment effects were found for sleepiness but not for performance or mood. Early morning caffeine significantly antagonized next day hypnotic-induced drowsiness and enhanced alertness in the subjects who received bed-time placebo. Flurazepam, 30 mg, subjects were more sleepy than all other groups. Although not significantly different, the flurazepam, 30 mg, group demonstrated a trend toward poorer performance and a more negative mood than all other groups. Caffeine most improved performance of this group. In all groups, sleepiness was greatest and performance and mood poorest in early morning trials and caffeine was most effective at this time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244120
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Dose level effects of triazolam on sleep and response to a smoke detector alarm (1987)
    Springer
    Psychopharmacology 91 (1987), S. 397-402 
    Details
    ISSN: 1432-2072
    Keywords: Human ; Benzodiazepines ; Triazolam ; Dose level ; Sleep structure ; Arousal threshold ; Smoke detector alarm ; Heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-six young adult, male subjects with sleep-onset insomnia were equally divided into placebo, 0.25 mg, and 0.5 mg triazolam groups to examine the effects of the hypnotic, with particular attention to dose level on efficacy, sleep stages, and awakening to a smoke detector alarm. On nights 1 and 4 of a five-consecutive-night protocol, a standard home smoke detector alarm was sounded during stage 2, 5 min after sleep onset, in slow wave sleep (SWS), and at the time of the early morning awakening. The alarm registered 78 dB SPL at the pillow. EEG arousal latency and reaction time to a button press were studied. Failure to awaken to three 1-min alarm presentations was scored as “no response.” Both dose levels produced similar reductions in sleep latency, decreases in SWS, increases in stage 2, and increases in sleep efficiency. Both dose levels showed similar sedative effects to the smoke alarm. Fifty percent of triazolam subjects failed to awaken on night 1 during SWS, and EEG arousal and response latencies were significantly slowed. Some drug tolerance or sensitization to the alarm was seen by night 4. By morning, all subjects were easily awakened on both nights. The 0.25 mg dose is clearly an effective dose level for both sleep efficacy and sedative effects to outside noise, which in some instances could pose potantial problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216003
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Acute, whole-body microwave exposure and testicular function of rats (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 8 (1987), S. 37-43 
    Details
    ISSN: 0197-8462
    Keywords: neurohormones ; testis ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Male Sprague-Dawley rats were exposed for 8 h to continuous-wave microwave radiation (MWR, 1.3 Ghz) at a mean specific absorbed dose rate of 9 mW/g. MWR exposure and sham-irradiation took place in unidirectionally energized cylindrical waveguide sections, within which the animals were essentially unrestrained. The MWR treatment in this setting was determined to yield an elevation of deep rectal temperature to 4.5 °C. The animals were taken for analysis at 6.5, 13, 26, and 52 days following treatment, which corresponded to 0.5, 1, 2, and 4 cycles of the seminiferous epithelium. Net mass of testes, epididymides, and seminal vesicles; daily sperm production (DSP) per testis and per gram of testis; and the number of epididymal sperm were determined. The levels of circulating follicle-stimulating hormone (FSH) and leutinizing hormone (LH) were derived via radioimmunoassay of plasma samples taken at the time of sacrifice. Despite the evident acute thermogenesis of the MWR at 9 mW/g, no substantial decrement in testicular function was found. We conclude that, in the unrestrained rat, whole body irradiation at 9 mW/g, while sufficient to induce evident hyperthermia, is not a sufficient condition for disruption of any of these key measures of testicular function.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250080106
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Testicular function of rats following exposure to microwave radiation (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 4 (1983), S. 107-114 
    Details
    ISSN: 0197-8462
    Keywords: spermatogenesis ; microwave radiation ; germinal tissue ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Male Sprague-Dawley rats were exposed for 6 h per day for nine days to pulse-modulated microwave radiation (1.3 GHz, at 1-μs pulse width, 600 pulses per second). Exposures were carried out in cylindrical waveguide sections at a mean dose rate of 6.3 mW/g; sham controls were treated similarly and received no irradiation. At time periods corresponding to 0.5, 1.0, 2.0, and 4.0 cycles of the seminiferous epithelium, groups of four shamirradiated and four irradiated rats were killed and the testes removed for analysis. Net mass of the testes, epididymides, and seminal vesicles; daily sperm production (DSP) per testis and per gram of testis; sperm morphology; and the number of epididymal sperm were determined. There were no statistically significant differences between the shamirradiated and irradiated groups with respect to any measured variable. In a group of seven surrogate animals of similar body mass, the dose rate of 6.3 mW/g caused a net change in body temperature (via rectal probe) of 1.5 °C.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250040202
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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