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  • 1
    Electronic Resource
    Electronic Resource
    The carcinogenic properties of topical PUVA (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 347-351 
    Details
    ISSN: 1432-069X
    Keywords: Methoxsalen ; PUVA-therapy ; Skin cancers ; Carcinogenesis, experimental
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The tumorigenic properties of topical methoxsalen (8-MOP) and trioxsalen (TMP) plus ultraviolet light A (UVA) were studied in NMRI female mice. The animals were treated three times weekly for 9 months, and followed up for 18 months. Acetonic solutions of TMP (0.1 mg in 0.2 ml) and 8-MOP (0.6 mg in 0.2 ml) were applied to the shaved back skin of the mice and irradiated with UVA. The doses needed to elicit equivalent phototoxic effects were 0.29 J/cm2 in the TMP group and 1.09 J/cm2 in the 8-MOP group. Papillomas, keratoacanthomas, and squamous cell carcinomas developed in the 8-MOP group only, and the first tumor was seen at 10 months after the beginning of the study. The results suggest that the carcinogenicity of these two modes of photochemotherapy may differ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418161
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultraviolet light inhibits nonimmunologic immediate contact reactions to benzoic acid (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 420-423 
    Details
    ISSN: 1432-069X
    Keywords: Nonimmunologic immediate contact reactions ; Contact urticaria ; Laser-Doppler flowmetry ; UV erythema ; Benzoic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of ultraviolet B (UVB) and ultraviolet A (UVA) irradiation on nonimmunologic immediate contact reactions (NIICRs) induced by benzoid acid (BA) was studied in 14 and 13 test subjects, respectively. 10×20 cm areas of the back skin were irradiated with 0.08, 0.16, and 0.24 J/cm2 UVB, and with 20 and 60 J/cm2 UVA. Five concentrations of BA were applied to the UV-exposed and nonexposed areas on the 1st, 3rd, 7th, and 21st day after UVB irradiation and on the 1st, 3rd, 7th, and 14th day after UVA irradiation. Forty minutes after BA application, erythema and edema reactions were observed visually, and changes in the skin blood flow were monitored using laser-Doppler flowmetry. The highest dose of UVB significantly inhibited NIICRs for 3 weeks. The lower doses of UVB had a weaker effect. Both doses of UVA diminished blood flow in NIICRs to lower concentrations of BA for 14 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429981
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Assessment of skin erythema by eye, laser Doppler flowmeter, spectroradiometer, two-channel erythema meter and Minolta chroma meter (1993)
    Springer
    Archives of dermatological research 285 (1993), S. 278-282 
    Details
    ISSN: 1432-069X
    Keywords: Skin colour ; Skin blood flow ; UVB erythema ; Immediate contact reactions ; Benzoic acid ; Methyl nicotinate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Visual grading, a laser Doppler flowmeter, a spectroradiometer, a two-channel erythema meter and a Minolta chroma meter were compared in the measurement of erythemas arising from immediate contact reactions produced either by 250 mM benzoic acid or 10 mM methyl nicotinate in petrolatum in an open application test or by ultraviolet irradiation. A good correlation between visual grading and objectively measured values was found for all the instruments, buth the laser Doppler flowmeter gave proportionally lower values for the ultraviolet erythemas than the skin reflectance meters, suggesting that these differ from erythemas induced by benzoic acid or methyl nicotinate. The laser Doppler flowmeter gave less repeatable results than other meters when measuring moderate and pronounced erythemas produced by ultraviolet irradiation. Measuring both the blood flow and the actual erythema may give more information about the reaction than either measurement system alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371596
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    Paper (German National Licenses)
    Fulltext
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