ISSN:
1432-0428
Keywords:
Insulin dependent diabetes
;
HLA complex
;
DR
;
Bf
;
DRw3/4 heterozygosity.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary HLA genotypes were ascertained in 53 French Caucasian families, comprising 68 juvenile onset insulin-dependent diabetic siblings. Among the 49 alleles detected at different loci in the HLA complex (A, C, B, Bf, DR) 4 appeared to occur at a significantly higher frequency among the 53 index cases than in a control series of 116 healthy individuals: HLA-B18 (p〈10-3), DRw3, DRw4 and BfF1 (p〈10-6). The excess of HLA identical affected siblings confirms genotype disequilibrium and supports the hypothesis of an HLA-linked gene(s) conferring susceptibility. There was no increase of homozygosity for HLA DRw3 and DRw4 whereas there was a marked excess heterozygosity for HLA DRw3/DRw4 in diabetic patients (32% versus 0% in the control series, p〈0.001). These data provide evidence for the existence of two cooperating genes, linked to each of the HLA DR alleles.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00275267
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