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  • 1
    Electronic Resource
    Electronic Resource
    Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 385-387 
    Details
    ISSN: 1432-1041
    Keywords: Diuretic ; drug interaction ; gastrointestinal absorption ; hydrochlorothiazide ; propantheline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Hydrochlorothiazide 75 mg was given twice p.o. to fasting subjects. In the second study they had been pretreated with propantheline 60 mg. Plasma and urine concentrations of hydrochlorothiazide were determined by GLC. Pretreatment with propantheline on average delayed the maximal plasma level of hct from 2.4 to 4.8 h (p〈0.05); and the total urinary recovery of hydrochlorothiazide by 48 h was increased from 49.3 mg to 66.9 mg (p〈0.005). It was concluded that propantheline increased substantially the absorption of the diuretic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644613
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bioavailability of two hydrochlorothiazide preparations (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 203-205 
    Details
    ISSN: 1432-1041
    Keywords: Bioavailability ; diuretics ; gastrointestinal ; absorption ; hydrochlorothiazide ; thiazides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight healthy volunteers received hydrochlorothiazide 75 mg as Dichlotride and Esidrex. Maximal plasma levels were significantly (p〈0.05) higher after Dichlotride than Esidrex, 512±189 and 376±70 ng/ml, respectively. However, the bioavailability of the two brands of hydrochlorothiazide did not differ significantly as judged by comparison of the AUC0→9h and AUC0→∞, and the urinary recovery of hydrochlorothiazide during 48 hrs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606411
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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