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  • 1
    Electronic Resource
    Electronic Resource
    A novel guanine N3 alkylation by antitumor antibiotic duocarmycin A
    Amsterdam : Elsevier
    Tetrahedron Letters 34 (1993), S. 2179-2182 
    Details
    ISSN: 0040-4039
    Keywords: DNA alkylation ; duocarmycin A
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)60376-3
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  • 2
    Electronic Resource
    Electronic Resource
    Synchronous expression of contractile proteins in mesangial cells and interstitial cells in IgA nephropathy (1999)
    Springer
    Clinical and experimental nephrology 3 (1999), S. 279-289 
    Details
    ISSN: 1437-7799
    Keywords: Key wordsα-Smooth muscle actin ; Myosin heavy chain ; Caldesmon ; Tropomyosin ; Mesangial cell ; Interstitial cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Phenotypic changes in glomerular mesangial cells and interstitial cells are considered to be closely associated with the progression of glomerulosclerosis and renal fibrosis in IgA nephropathy. To further evaluate the relevance of phenotypic changes, we examined the expression of four different contractile proteins as markers of the phenotypic changes. Methods. The expression of nonmuscle myosin heavy chain isoform (SMemb), α-smooth muscle actin (α-SMA), caldesmon (CaD), and tropomyosin (TM) was evaluated by indirect immunofluorescent studies in renal biopsy specimens from 21 patients with IgA nephropathy. The relationships with the histological parameters and clinical parameters were analyzed. Results. Pronounced expression (score of 2 or more) of contractile proteins was observed in the majority of the patients (57%–90%) compared with controls. There was no significant relationship between the glomerular expression score of any contractile protein and the proliferation index or sclerotic index. Daily urinary protein excretion in the group expressing low levels of caldesmon in the glomerulus was significantly lower than that in the group expressing high levels (P 〈 0.05). There were significant correlations among the glomerular expressions of these contractile proteins, except for TM (P 〈 0.05). All contractile proteins were expressed in tubulointerstitial lesions, and only SMemb expression was detected in tubular epithelial cells. The interstitial scores of all contractile proteins increased in parallel with the degree of tubulointerstitial lesion (P 〈 0.05). Conclusions. Contractile proteins appeared to be coordinately expressed in the glomerulus and the interstitium in IgA nephropathy, which may reflect the mechanical stress involved with glomerulonephritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050048
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  • 3
    Electronic Resource
    Electronic Resource
    The recovery of staphylococcal enterotoxin from bacterial culture supernatants by ion exchangeThis work was supported by contributions from various companies and associations of the food industries. (1961)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Biochemical and Microbiological Technology and Engineering 3 (1961), S. 41-50 
    Details
    ISSN: 0368-1467
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A method has been developed for the recovery of enterotoxin from bacterial culture supernatants of staphylococcus strain S-6 by use of the ion-exchange resin Amberlite XE-64 (IRC-50). The enterotoxin from 200 ml of bacterial culture supernatant diluted with one volume of water and adjusted to pH 6 can be removed with 1 g of resin pretreated with 0·02 M sodium phosphate, pH 6·2. The enterotoxin is recovered from the resin with 0·2 M sodium phosphate, pH 6·2, with subsequent precipitation with EtOH at -10°C, dialysis, and freeze drying. Partially purified preparations containing 1 emetic dose per 50μg were obtained.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbmte.390030106
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    Paper (German National Licenses)
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