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Antitumor activity of marine algae (1990)

Noda, Hiroyuki ; Amano, Hideomi ; Arashima, Koichi ; [et al.]

Springer

Hydrobiologia 204-205 (1990), S. 577-584

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ISSN: 1573-5117

Keywords: antitumor ; Ehrlich carcinoma ; lipids ; Meth-A fibrosarcoma ; polysaccharides ; seaweed

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Powdered tissue from 46 species of air-dried marine algae (four green, 21 brown and 21 red algae) were screened for antitumor activity. Significant activity against Ehrlich carcinoma was found in the brown algae Scytosiphon lomentaria (69.8% inhibition), Lessonia nigrescens (60.0%), Laminaria japonica (57.6%), Sargassum ringgoldianum (46.5%), the red algae Porphyra yezoensis (53.2%) and Eucheuma gelatinae (52.1%) and the green alga Enteromorpha prolifera (51.7%). Five brown and four red algae showed appreciable antitumor activity against Meth-A fibrosarcoma. To identify specific molecules with antitumor activity, 15 kinds of polysaccharide preparations of seaweed origin and 24 kinds of lipid fractions extracted from various seaweeds were tested. Appreciable inhibition of Ehrlich carcinoma was found for fucoidan preparations from Undaria pinnatifida and Sargassum ringgoldianum, for carrageenans and for porphyran. Several glycolipid and phospholipid fractions from brown and red algae were effective against Meth-A fibrosarcoma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00040290

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Cellulase production from immobilized growing cell composites prepared by radiation polymerization (1984)

Kumakura, Minoru ; Kaetsu, Isao ; Nisizawa, Kazutosi

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 26 (1984), S. 17-21

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ISSN: 0006-3592

Keywords: Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: The cellulase production from immobilized Trichoderma reesei composites prepared by radiation polymerization at low temperature was studied. The production of cellulase from the cells irradiated by radiation was slightly retarded at the initial stage of the culture, but was immediately recovered. The production of cellulase resulting from the growth of the immobilized cells proceeds efficiently in the composite having a porous polymer matrix, in which the productivity of cellulase varied with the hydrophilicity, the shape of the composite, monomer, and cell concentration. It was found that cellulase produced by immobilized growing cell composites effectively hydrolyzed cellulosic wastes such as newspaper and chaff which are pretreated by irradiation and crushing.

Additional Material: 7 Ill.