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  • Event-related potential  (3)
  • Biochemistry and Biotechnology  (2)
  • Herpes simplex virus-thymidine kinase  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Oddball-evoked P300-based method of deception detection in the laboratory II: Utilization of non-selective activation of relevant knowledge
    Amsterdam : Elsevier
    International Journal of Psychophysiology 12 (1992), S. 289-306 
    Details
    ISSN: 0167-8760
    Keywords: Deception ; Event-related potential ; Lie detection ; P300
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-8760(92)90067-L
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Event-related potentials in the dual task paradigm: P300 discriminates engaging and non-engaging films when film-viewing is the primary task
    Amsterdam : Elsevier
    International Journal of Psychophysiology 12 (1992), S. 221-232 
    Details
    ISSN: 0167-8760
    Keywords: Attention ; Dual-task paradigm ; Event-related potential ; P300 ; Resource allocation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-8760(92)90060-O
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Event-related potential correlates of implicit priming and explicit memory tasks
    Amsterdam : Elsevier
    International Journal of Psychophysiology 15 (1993), S. 197-206 
    Details
    ISSN: 0167-8760
    Keywords: Event-related potential ; Implicit priming ; Memory task
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-8760(93)90003-8
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 455-462 
    Details
    ISSN: 1432-1440
    Keywords: Key words Gene therapy ; Adenovirus ; Ovarian carcinoma ; Herpes simplex virus-thymidine kinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The herpes simplex virus thymidine kinase gene is the most widely utilized toxin for selective killing of carcinoma cells. Expression of the viral thymidine kinase gene renders cells sensitive to the toxic effects of nucleoside analogs such as ganciclovir. An advantage of this system is the ”bystander effect” whereby thymidine kinase transduced tumor cells elicit a toxic effect on surrounding nontransduced tumor cells. Ovarian carcinoma appears to be an ideal candidate for gene therapy as the majority of women present with advanced stage disease, have poor prognosis for long-term survival and have the disease confined within the peritoneal cavity. Therefore the utility of an adenoviral vector to elicit an in vitro bystander effect in ovarian carcinoma cells and the therapeutic efficacy of such a system in vivo was undertaken. Immunocompetent animals were utilized to determine the maximum dose of adenovirus that could be administered without any undesirable side effects and that preimmunization had no effects on subsequent challenge. SCID mice were orthotopically transplanted with human ovarian carcinoma cells and, after establishment of tumor, given a recombinant adenovirus expressing either the herpes simplex virus thymidine kinase or the Escherichia coli β-galactosidase gene. Half the animals from each viral group were treated with either a ganciclovir regiment (50 mg/kg daily for 14 days) or an equal volume of serum-free media. A subset of mice were killed following drug treatment and analyzed for tumor reduction. The remaining animals were followed daily for survival. The animals treated with the recombinant adenovirus expressing the herpes simplex virus thymidine kinase gene and ganciclovir had significant reduction in overall tumor burden and demonstrated statistically significant prolongation in overall survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050047
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 455-462 
    Details
    ISSN: 1432-1440
    Keywords: Gene therapy ; Adenovirus ; Ovarian carcinoma ; Herpes simplex virus-thymidine kinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The herpes simplex virus thymidine kinase gene is the most widely utilized toxin for selective killing of carcinoma cells. Expression of the viral thymidine kinase gene renders cells sensitive to the toxic effects of nucleoside analogs such as ganciclovir. An advantage of this system is the “bystander effect” whereby thymidine kinase transduced tumor cells elicit a toxic effect on surrounding nontransduced tumor cells. Ovarian carcinoma appears to be an ideal candidate for gene therapy as the majority of women present with advanced stage disease, have poor prognosis for long-term survival and have the disease confined within the peritoneal cavity. Therefore the utility of an adenoviral vector to elicit an in vitro by-stander effect in ovarian carcinoma cells and the therapeutic efficacy of such a system in vivo was undertaken. Immunocompetent animals were utilized to determine the maximum dose of adenovirus that could be administered without any undesirable side effects and that preimmunization had no effects on subsequent challenge. SCID mice were orthotopically transplanted with human ovarian carcinoma cells and, after establishment of tumor, given a recombinant adenovirus expressing either the herpes simplex virus thymidine kinase or the Escherichia coli β-galactosidase gene. Half the animals from each viral group were treated with either a ganciclovir regiment (50 mg/kg daily for 14 days) or an equal volume of serum-free media. A subset of mice were killed following drug treatment and analyzed for tumor reduction. The remaining animals were followed daily for survival. The animals treated with the recombinant adenovirus expressing the herpes simplex virus thymidine kinase gene and ganciclovir had significant reduction in overall tumor burden and demonstrated statistically significant prolongation in overall survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217521
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Crystallization and preliminary X-ray analysis of Pit-1 POU domain complexed to a 28 base pair DNA element (1996)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 24 (1996), S. 263-265 
    Details
    ISSN: 0887-3585
    Keywords: X-ray crystallography ; POU-domain ; transcription factor ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The POU domain, representing an approximately 150 amino acid conserved region, serves as the DNA-recognition domain for a large number of eukaryotic transcription factors. Bipartite in nature, the POU domain is comprised of a N-terminal POU-specific domain connected by a linker of variable length to a C-terminal homeodomain. We report here co-crystals of pituitary-specific factor Pit-1 POU domain bound as a dimer to a 28 bp DNA fragment. The crystals diffract to at least 2.3 Å in resolution and belong to space group P1 with unit cell dimensions of a = 42.5 Å, b = 50.1 Å, c = 55.8 Å, α = 76.7°, β = 79.3°, and γ = 67.2°.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 7
    Electronic Resource
    Electronic Resource
    Theoretical and experimental studies on the influence of ultrasound on immobilized enzymes (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 30 (1987), S. 928-935 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Experimental investigations on α-amylase and glucoamylase bound to porous polystyrene show that the activity of immobilized enzymes can be raised in the presence of an ultrasonic field. The maximum activity increase in a flow cuvette at 7.6 MHz and a sound intensity of 5 kW/m2 amounts to more than 200% under the given experimental conditions. A mathematical model based on the differential equation for the interior and exterior substrate transport is set up and solved numerically. From the theoretical considerations and the experiments it is evident that the mechanism of the ultrasonic effect can be explained in terms of a reduction of the unstirred diffusion layer around the matrix particles.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260300803
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    Paper (German National Licenses)
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