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  • 1
    Digitale Medien
    Digitale Medien
    Biodistribution of iodine-125 tyramine transforming growth factor α antisense oligonucleotide in athymic mice with a human mammary tumour xenograft following intratumoral injection (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 448-452 
    Details
    ISSN: 1619-7089
    Schlagwort(e): Transforming growth factor α ; Antisense phosphodiester oligonucleotide ; Radioiodine labelling ; Biodistribution
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The Watson-Crick base pairing rule provides the underlying principle for the antisense (AS) approach to inhibiting gene expression. Transforming growth factor α (TGFα) was the first growth factor to be associated with tumorigenesis, thus making the TGFα (mRNA) a potential target for AS therapy and offering the potential for monitoring of the progression of malignancy by non-invasive imaging with radiolabelled AS phosphodiester. Probe labelling and biodistribution were studied in the present report. A 23-mer oligonucleotide sequence was synthesized and grafted in 5′ with a tyramine group which was further radioiodinated. The radiolabelled AS was injected intratumorally in mammary tumour-bearing BALB/c mice (3 weeks after inoculation of 7·106 NS2T2A mammary cells). Biodistribution was monitored by sequential scintigraphy and organ radioactivity after autopsy. The 5′ tyramine group allowed specific and stable radiolabelling of the AS with125I. The125I AS oligonucleotide was rapidly cleared from the tumour by intestine and kidneys. Four hours after intratumoral injection, 6.5%±1.5% of the dose was retained in the tumour as non-degraded125I AS. It is concluded that 5′ tyraminylated AS provides information on the biodistribution of AS oligonucleotide following intratumoral injection. These data will contribute to the pharmacology of AS oligonucleotides which can be used for therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01247375
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  • 2
    Digitale Medien
    Digitale Medien
    Structure of nitrogen molecular clusters (N2)n with 13≤n≤55 (1999)
    Springer
    The European physical journal 9 (1999), S. 189-193 
    Details
    ISSN: 1434-6079
    Schlagwort(e): PACS: 36.40.Mr Spectroscopy and geometrical structure of clusters
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract. We investigate the structural properties of nitrogen molecular clusters (N2) n using classical Monte Carlo simulations and optimization methods. As is the case for argon clusters, we find polyicosahedral (anti-Mackay) geometries above 13 molecules, and multilayer icosahedra with uncomplete outer shell (Mackay) geometries below 55 molecules. The crossover point between these two kinds of structures is located near 42 molecules, whereas it is at only 31 for argon. With a simple three-body (Axilrod–Teller) potential added to the standard Lennard–Jones model, we interpret this difference as the result of the strong anisotropy of the molecular potential.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s100530050424
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