ISSN:
1434-0879
Keywords:
Biological response modifiers
;
Bladder cancer
;
Alpha-interferon
;
Gamma-interferon
;
Tumor necrosis factor-alpha
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We investigated the activity of alpha-interferon (α-IFN), gamma-interferon (γ-IFN) and tumor necrosis factor-alpha (TNF-α) in a panel of ten human bladder tumor cell lines. All cytokines were tested at concentrations of 100–10000 U/ml in a clonogenic assay system. We found that α-IFN was active against five of the ten lines while γ-IFN was only active against one line. TNF was active against five of the ten lines. Maximum synergisms were obtained between the α-IFN and TNF, occurring in nine of the ten cell lines. We conclude that α-IFN and TNF are active as single agents and synergistic when used together in vitro in human bladder tumor cell lines.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00541901
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