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Gastric emptying andHelicobacter pylori infection in duodenal ulcer disease (1996)

Perri, Francesco ; Ghoos, Yvo F. ; Maes, Bart D. ; [et al.]

Springer

Digestive diseases and sciences 41 (1996), S. 462-468

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ISSN: 1573-2568

Keywords: Helicobacter pylori ; duodenal ulcer ; gastric emptying ; [13C]urea breath test

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The pathogenetic link betweenHelicobacter pylori gastritis and duodenal ulcer is still unknown. Fast gastric emptying of liquids might be important in the pathogenesis of gastric metaplasia of the duodenum and duodenal ulcer through an increased exposure of the duodenum to gastric acid. InH. pylori-infected subjects, an abnormal gastric emptying could affect urea breath test results and correlate with the histological gastritis. This study was performed to evaluate the gastric emptying of liquids in duodenal ulcer patients withH. pylori infection and the possible relation between the bacterial load, gastric emptying, and urea breath test results. Seventeen duodenal ulcer patients withH. pylori gastritis and 15 healthy volunteers were studied by a combined [14C]octanoic acid and [13C]urea breath test to evaluate gastric emptying rate andH. pylori status simultaneously. Endoscopy with antral biopsies was performed in all duodenal ulcer patients. Duodenal ulcer patients withH. pylori infection have a normal liquid gastric emptying that is unrelated with the histological severity of gastritis. The urea breath test results and the gastric emptying parameters do not correlate with histology. A significant correlation between the gastric emptying and the urea hydrolysis rate is found. It is concluded thatH. pylori infection in duodenal ulcer patients is not associated with abnormally fast liquid gastric emptying, and this finding should be taken into account when a causal link betweenH. pylori infection and duodenal ulcer disease is searched for. The correlation between gastric emptying and urea hydrolysis rate explains why no conclusions on intragastric bacterial load can be drawn from the urea breath test results.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02282319

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Oral malodor, assessed by closed-loop, gas chromatography, and ion-trap technology (1997)

Claus, Dirk ; Geypens, Benny ; Ghoos, Yvo ; [et al.]

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 20 (1997), S. 94-98

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ISSN: 0935-6304

Keywords: Capillary gas chromatography ; Mass spectrometry ; Closed loop ; Biomedical volatile organic compounds ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A method is described for the analysis of volatile organic compounds in saliva and tongue coating samples. The techniue is based on an off-line preconcentration step by means of a closed-loop trapping system followed by gas chromatography-ion trap detection. With the closed-loop technique, the volatile organic compounds(VOCs) are released from the matrix and trapped on an adsorbent without interference of water. The VOCs are released from the adsorbent into the gas chromatograph by thermdesorption. After separation, identification of the compounds is performed by ion trap technology.By this technique 82 compounds could be demonstrated in saliva and tongue coating samples. The technique is also used to demonstrate the formation of volatile bacterial fermentation compounds when a protein substrate is added to tongue coating samples. It is considered a very promising tool in further research on oral malodor.

Additional Material: 3 Ill.