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Increased permeability of macroscopically normal small bowel in Crohn's disease (1994)

Peeters, Marc ; Ghoos, Yvo ; Maes, Bart ; [et al.]

Springer

Digestive diseases and sciences 39 (1994), S. 2170-2176

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ISSN: 1573-2568

Keywords: [51Cr]EDTA ; PEG-400 ; intestinal permeability ; Crohn's disease

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract To investigate permeability alterations of the macroscopically normal jejunum in Crohn's disease, the permeation of two probes was measured during perfusion of an isolated jejunal segment. The data were compared with the results obtained by the standard per oral test in the same patients. Test probes were PEG-400 and [51Cr]EDTA. Ten normal individuals, 12 patients with Crohn's ileitis or ileocolitis, and seven patients with isolated Crohn's colitis all with normal jejunum on x-ray series were studied. Upon perfusion of the proximal small bowel, the 3-hr [51Cr]EDTA excretion was significantly increased in ileitis patients (P=0.023) as compared to normals. The excretion exceeded the highest value of normals in eight of 12 ileitis patients. The excretion in Crohn's colitis patients was not significantly increased (P=0.24) and abnormal excretion was found only in one of the Crohn's colitis patients. PEG-400 permeation during perfusion did not differentiate between the groups, but five of the seven patients with isolated Crohn's colitis had PEG-400 excretion exceeding the highest value in normals. Overall, 13 of the 19 patients had increased permeation of one of the two probes through jejunal mucosa during perfusion. These data suggest that the permeability is increased in the majority of patients even in segments that seem normal on x-ray.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02090367

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Oral malodor, assessed by closed-loop, gas chromatography, and ion-trap technology (1997)

Claus, Dirk ; Geypens, Benny ; Ghoos, Yvo ; [et al.]

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 20 (1997), S. 94-98

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ISSN: 0935-6304

Keywords: Capillary gas chromatography ; Mass spectrometry ; Closed loop ; Biomedical volatile organic compounds ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A method is described for the analysis of volatile organic compounds in saliva and tongue coating samples. The techniue is based on an off-line preconcentration step by means of a closed-loop trapping system followed by gas chromatography-ion trap detection. With the closed-loop technique, the volatile organic compounds(VOCs) are released from the matrix and trapped on an adsorbent without interference of water. The VOCs are released from the adsorbent into the gas chromatograph by thermdesorption. After separation, identification of the compounds is performed by ion trap technology.By this technique 82 compounds could be demonstrated in saliva and tongue coating samples. The technique is also used to demonstrate the formation of volatile bacterial fermentation compounds when a protein substrate is added to tongue coating samples. It is considered a very promising tool in further research on oral malodor.

Additional Material: 3 Ill.