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  • 1
    Electronic Resource
    Electronic Resource
    Quantitative Bestimmung der Wirksamkeit von Hochdruckmittel-Kombinationen (1969)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 262 (1969), S. 189-196 
    Details
    ISSN: 1432-1912
    Keywords: Antihypertensive Activity ; Methyldopa ; Reserpine ; Guanacline ; Drug Combinations ; Biometrics ; Antihypertensive Wirkung ; Methyldopa ; Reserpin ; Guanacline ; Kombinationen ; Biometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über eine Methode berichtet, die bei der Prüfung von Arzneimittelkombinationen die Bestimmung der biometrisch definierten relativen Kombinationswirksamkeit gestattet. Untersucht wurden an Ratten mit experimentellem renalen Hochdruck Kombinationen von antihypertensiv wirksamen Stoffen. Die Kombinationen α-Methyldopa-Guanacline und Reserpin-Guanacline wirkten signifikant überadditiv, die Kombination α-Methyldopa-Reserpin allenfalls additiv.
    Notes: Summary A new method is described which permits the determination of the biometrically defined relative combined activity of drug combinations. Combinations of substances with antihypertensive action were investigated on rats with experimental renal hypertension. The effects of the combinations α-methyldopa-guanacline and reserpine-guanacline were significantly more than additive, the effect of the combination α-methyldopa-reserpine was at most, additive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00537659
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  • 2
    Electronic Resource
    Electronic Resource
    α-Sympathicomimetische Eigenschaften als Ursache der blutdrucksteigernden und blutdrucksenkenden Wirkung von BAY 1470 (2-(2,6-Xylidino)-5,6-dihydro-4H-1,3-thiazinhydrochlorid) (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 268 (1971), S. 348-360 
    Details
    ISSN: 1432-1912
    Keywords: Sympathomimetics ; Blood Pressure ; Central Nervous System ; Sympathicomimetica ; Blutdruck ; Zentralnervensystem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Phentolamine antagonizes the pressor response as well as the response of the nictitating membrane of the cat to BAY 1470. After propranolol the pressor response to BAY 1470 is unchanged while that to adrenaline is increased. 2. In concentrations of up to 10−3 g/ml BAY 1470 is devoid of any activity on isolated guinea-pig atria; hence, BAY 1470 does not seem to act onβ-receptors. 3. BAY 1470 has noindirect sympathomimetic effects. Cocaine antagonizes the pressor effect of tyramine but not that of BAY 1470. Pretreatment with reserpine does not reduce the pressor response to BAY 1470. The output of noradrenaline from the spleen does not increase during perfusion with BAY 1470. 4. The initial pressor response to BAY 1470 is followed by a prolonged fall in blood pressure; the latter seems to be due to an inhibition of the release of noradrenaline from the peripheral sympathetic neurones as well as to a central site of action. The peripheral site of action could be demonstrated by a diminished output of noradrenaline from the splenic nerves following electrical stimulation during perfusion with BAY 1470. The central origin of the depressor response has been demonstrated by its occurence during perfusion of the fourth ventricle with BAY 1470. 5. As the depressor response following the ventricular perfusion with BAY 1470 is inhibited by phentolamine and dibenzyline perfusion of the ventricle, the central depressor action seems to be mediated byα-receptors located in the vicinity of the fourth ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997267
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  • 3
    Electronic Resource
    Electronic Resource
    Central nervous α-adrenergic receptors and the mode of action of α-methyldopa (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 285-300 
    Details
    ISSN: 1432-1912
    Keywords: α-Adrenergic Receptors ; α-Methyldopa ; Catecholamines ; Central Activity ; Central Nervous System ; Blood Pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experiments in cats with perfusion of the fourth and parts of the third cerebral ventricle gave the following results: 1. Perfusions with α-methyldopa, α-methyldopamine, α-methylnoradrenaline, noradrenaline, or tyramine produced a significant decrease of the systemic arterial blood pressure. A dose-response relationship of this effect was demonstrated with noradrenaline and α-methylnoradrenaline. 2. The blood pressure lowering effect of the amines was inhibited or abolished by perfusion with phentolamine or yohimbine. 3. The depressor effect of perfusions with tyramine was inhibited after addition of 2μg/ml cocaine to the perfusion fluid. Cocaine perfusion enhanced the depressor effect of α-methylnoradrenaline. 4. In the reserpine-pretreated cat the effect of tyramine was strongly inhibited. α-Methylnoradrenaline had no effect under these conditions. 5. Perfusions with angiotensin produced an increase of the peripheral blood pressure, while isoprenaline and propranolol showed no significant activity. 6. In the intact anaesthetized, as well as in the spinal, cat the intravenous pressor activities of noradrenaline and α-methylnoradrenaline were nearly identical. The response of the isolated aortic strip of the rat was somewhat more pronounced to α-methylnoradrenaline than to noradrenaline. 7. The results of these investigations are in favour of the hypothesis that in the brain stem an α-receptor mechanism exists, which is able to mediate a blood pressure decreasing effect of centrally applied catecholamines. The central hypotensive action of α-methyldopa may be explained by this mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500607
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    Paper (German National Licenses)
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