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  • 1
    Electronic Resource
    Electronic Resource
    Alpha- und beta-sympathicomimetische Wirkungen am elektrisch gereizten isolierten Meerschweinchenileum (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 195-207 
    Details
    ISSN: 1432-1912
    Keywords: Acetylcholine ; Guinea-pig Ileum ; Morphine ; Sympatholytics ; Sympathomimetics ; Acetylcholin ; Meerschweinchenileum ; Morphin ; Sympathicolytica ; Sympathicomimetica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The contractions of the isolated, electrically stimulated guinea-pig ileum during ganglionic blockade by Hexamethonium are inhibited by BAY 1470 [2-(2,6-Dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine], Morphine, Naphazoline, Isoprenaline, Noradrenaline and Adrenaline. These drugs are approximately equipotent in producing inhibition. 2. The inhibitory effects of Noradrenaline and Isoprenaline are diminished only by Propranolol and those of BAY 1470 and Naphazoline are abolished only by Phentolamine. The inhibitory effect of Adrenaline is diminished both by Propranolol and by Phentolamine. Neither Propranolol nor Phentolamine influence the Morphine induced effect. 3. Noradrenaline and Isoprenaline inhibit the electrically stimulated contractions and the effects of added Acetylcholine to the same extent. BAY 1470, Morphine and Naphazoline diminish only the effect of electrical stimulation and not that of Acetylcholine. Adrenaline inhibits both, but against the electrically induced contractions it is effective in lower concentrations than against the action of added Acetylcholine. 4. The results of these and of preceding investigations indicate that therelease of Acetylcholine from the parasympathetic nerve can be inhibited by stimulatinga-adrenergic, and theaction of Acetylcholine by stimulatingβ-adrenergic mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997092
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  • 2
    Electronic Resource
    Electronic Resource
    α-Sympathicomimetische Eigenschaften als Ursache der blutdrucksteigernden und blutdrucksenkenden Wirkung von BAY 1470 (2-(2,6-Xylidino)-5,6-dihydro-4H-1,3-thiazinhydrochlorid) (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 268 (1971), S. 348-360 
    Details
    ISSN: 1432-1912
    Keywords: Sympathomimetics ; Blood Pressure ; Central Nervous System ; Sympathicomimetica ; Blutdruck ; Zentralnervensystem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Phentolamine antagonizes the pressor response as well as the response of the nictitating membrane of the cat to BAY 1470. After propranolol the pressor response to BAY 1470 is unchanged while that to adrenaline is increased. 2. In concentrations of up to 10−3 g/ml BAY 1470 is devoid of any activity on isolated guinea-pig atria; hence, BAY 1470 does not seem to act onβ-receptors. 3. BAY 1470 has noindirect sympathomimetic effects. Cocaine antagonizes the pressor effect of tyramine but not that of BAY 1470. Pretreatment with reserpine does not reduce the pressor response to BAY 1470. The output of noradrenaline from the spleen does not increase during perfusion with BAY 1470. 4. The initial pressor response to BAY 1470 is followed by a prolonged fall in blood pressure; the latter seems to be due to an inhibition of the release of noradrenaline from the peripheral sympathetic neurones as well as to a central site of action. The peripheral site of action could be demonstrated by a diminished output of noradrenaline from the splenic nerves following electrical stimulation during perfusion with BAY 1470. The central origin of the depressor response has been demonstrated by its occurence during perfusion of the fourth ventricle with BAY 1470. 5. As the depressor response following the ventricular perfusion with BAY 1470 is inhibited by phentolamine and dibenzyline perfusion of the ventricle, the central depressor action seems to be mediated byα-receptors located in the vicinity of the fourth ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997267
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  • 3
    Electronic Resource
    Electronic Resource
    Quantitative Bestimmung der Wirksamkeit von Hochdruckmittel-Kombinationen (1969)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 262 (1969), S. 189-196 
    Details
    ISSN: 1432-1912
    Keywords: Antihypertensive Activity ; Methyldopa ; Reserpine ; Guanacline ; Drug Combinations ; Biometrics ; Antihypertensive Wirkung ; Methyldopa ; Reserpin ; Guanacline ; Kombinationen ; Biometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über eine Methode berichtet, die bei der Prüfung von Arzneimittelkombinationen die Bestimmung der biometrisch definierten relativen Kombinationswirksamkeit gestattet. Untersucht wurden an Ratten mit experimentellem renalen Hochdruck Kombinationen von antihypertensiv wirksamen Stoffen. Die Kombinationen α-Methyldopa-Guanacline und Reserpin-Guanacline wirkten signifikant überadditiv, die Kombination α-Methyldopa-Reserpin allenfalls additiv.
    Notes: Summary A new method is described which permits the determination of the biometrically defined relative combined activity of drug combinations. Combinations of substances with antihypertensive action were investigated on rats with experimental renal hypertension. The effects of the combinations α-methyldopa-guanacline and reserpine-guanacline were significantly more than additive, the effect of the combination α-methyldopa-reserpine was at most, additive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00537659
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    Paper (German National Licenses)
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