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  • Biosynthesis  (2)
  • Capillary electrophoresis  (2)
  • Heart  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Biosynthesis of poly(3-hydroxyalkanoate) from amino acids
    Amsterdam : Elsevier
    International Journal of Biological Macromolecules 14 (1992), S. 321-325 
    Details
    ISSN: 0141-8130
    Keywords: Biosynthesis ; amino acid ; poly(3-hydroxyalkanoate) ; threonine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0141-8130(05)80072-8
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Biosynthesis of poly(3-hydroxyalkanoates) from threonine
    Amsterdam : Elsevier
    International Journal of Biological Macromolecules 14 (1992), S. 117-118 
    Details
    ISSN: 0141-8130
    Keywords: Alcaligenes eutrophus ; Biosynthesis ; amino acid ; polyester
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0141-8130(92)90008-V
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experimental hypertension of the rat: Reciprocal changes of norepinephrine turnover in heart and brain-stem (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 268 (1971), S. 125-139 
    Details
    ISSN: 1432-1912
    Keywords: Experimental Hypertension ; Norepmephrine Turnover ; Heart ; Hypothalamus ; Medulla Oblongata ; Chlorisondamine ; DOCA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In experimental hypertensive rats (DOCA-implantation, 1% saline as drinking-water, encapsulation of the left kidney), the norepinephrine turnover in peripheral sympathetically innervated organs and the central nervous system was determined either by the decay in endogenous norepinephrine after inhibition of tyrosine hydroxylase or by the ecayd in the specific norepinephrine activity after intravenous or intraventricular administration of3H-norepinephrine. In the heart, the norepinephrine turnover was accelerated in proportion to the rise in blood pressure. In hypothalamus and medulla oblongata, the turnover was delayed reciprocally to the acceleration in the heart. No changes were seen in the residual parts of the brain. Administration of chlorisondamine, a quaternary ganglionic blocking agent which does not cross the blood-brain barrier, resulted in a normalization of the increased cardiac norepinephrine turnover, whereas the changes in the brain persisted. Implantation of DOCA alone produced neither a rise in blood pressure nor changes in norepinephrine turnover. The results presented are compatible with the hypothesis that, in this form of experimental hypertension, the delay in norepinephrine turnover in the brain-stem is causally related to the increased activity of the peripheral sympathetic nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01020067
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  • 4
    Electronic Resource
    Electronic Resource
    Genetically hypertensive rats: Relationship between the development of hypertension and the changes in norepinephrine turnover of peripheral and central adrenergic neurons (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 271 (1971), S. 157-169 
    Details
    ISSN: 1432-1912
    Keywords: Spontaneous Hypertension ; Norepinephrine Turnover ; Heart ; Salivary Gland ; Brain Stem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In genetically hypertensive rats, the norepinephrine turnover of peripheral and central adrenergic neurons was determined either by the decline in endogenous norepinephrine after inhibition of tyrosine hydroxylase or by the decay in the specific activity of norepinephrine after labelling the stores by intravenous or intraventricular injection of3H-norepinephrine. In the periphery (heart and submaxillary gland), the norepinephrine turnover of genetically hypertensive rats was reduced in proportion to the rise in systolic blood pressure. In the hypothalamus, medulla-pons and the residual parts of the brain, the turnover was unchanged both in the prehypertensive and the hypertensive state. The results indicate that the central adrenergic neurons, involved in the control of blood pressure, may act independently from the activity of peripheral baroreceptors. The elevated blood pressure resulting from an enhanced peripheral vascular reactivity to the physiological neurotransmitter norepinephrine may induce a compensatory inhibition of the activity of the peripheral adrenergic neurons. In the genetically hypertensive rats, neither the peripheral nor the central adrenergic nervous system seems to play a primary role in the development of hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00998577
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Enantiomeric separation of trimetoquinol, denopamine and timepidium by capillary electrophoresis and HPLC and the application of capillary electrophoresis to the optical purity testing of the drugs (1995)
    Springer
    Chromatographia 40 (1995), S. 638-644 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Capillary electrophoresis ; Enantiomer separation ; Trimetoquinol ; Denopamine ; Timepidium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Two methods for the direct separation of the enantiomers of trimetoquinol hydrochloride, denopamine and timepidium bromide were investigated, namely capillary zone electrophoresis (CZE) using cyclodextrins (CDs) (CD-CZE) and high-performance liquid chromatography (HPLC) using chiral stationary phases (CSPs). By CZE, separation of the enantiomers of trimetoquinol was successfully achieved when using β-cyclodextrin (β-CD), heptakis(2,6-di-0-methyl)-β-cyclodextrin (DM-β-CD) and β-CD polymer, but direct HPLC separation of the enantiomers was not successful. The enantiomers of denopamine were successfully separated by both CZE, employing DM-β-CD under acidic conditions, and HPLC, with cyclodextrin immobilized CSPs (CD-CSPs). Timepidium bromide, which is a racemic drug, was successfully enantioseparated by both CD-CZE and HPLC with CD-CSPs. The CD-CZE mode was selected as the optical purity testing method for trimetoquinol and denopamine because of the superiority of capillary electrophoretic (CE) techniques. Method validation results obtained clearly show that the CE method would be useful as an quality control method for assessing the optical purity of the drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02315130
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  • 6
    Electronic Resource
    Electronic Resource
    Enantiomer separation by capillary electrophoresis using DEAE-dextran and aminoglycosidic antibiotics (1996)
    Springer
    Chromatographia 43 (1996), S. 426-430 
    Details
    ISSN: 1612-1112
    Keywords: Capillary electrophoresis ; Aminoglycosidic antibiotics ; DEAE-dextran ; Drugs ; Enantiomer separation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Diethylaminoethyl (DEAE) dextran hydrochloride and three kinds of aminoglycosidic antibiotics; fradiomycin sulfate, kanamycin sulfate and streptomycin sulfate, were employed as chiral selectors in capillary electrophoresis, enantiomer separation. These selectors are cationic or basic because of amino functionality and therefore used for enantiomer separation of acidic compounds. To avoid adsorption of the basic or cationic selectors on the capillary inner surface, a coated capillary was employed. Among those tested, enantiomers of binaphthyl compounds and synthetic intermediates of diltiazem analogues were separated. Methanol addition was effective for the improvement of peak shape and resolution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02271023
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