ISSN:
1619-7089
Keywords:
Key words: High linear energy transfer
;
Bismuth-213
;
Astatine-211
;
Bismuth-212
;
Actinium-225
;
Alpha particle-emitting radionuclides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. This review discusses the application of alpha particle-emitting radionuclides in targeted radioimmunotherapy. It will outline the production and chemistry of astatine-211, bismuth-212, lead-212, actinium-225, bismuth-213, fermium-255, radium-223 and terbium-149, which at present are the most promising alpha-emitting isotopes available for human clinical use. The selective cytotoxicity offered by alpha particle-emitting radioimmunoconstructs is due to the high linear energy transfer and short particle path length of these radionuclides. Based upon the pharmacokinetics of alpha particle-emitting radioimmunoconstructs, both stochastic and conventional dosimetric methodology is discussed, as is the preclinical and initial clinical use of these radionuclides conjugated to monoclonal antibodies for the treatment of human neoplasia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002590050306
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