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  • 1
    Electronic Resource
    Electronic Resource
    A prospective, randomized controlled trial of inpatient versus outpatient continence programs in the treatment of urinary incontinence in the female (1996)
    Springer
    International urogynecology journal 7 (1996), S. 260-263 
    Details
    ISSN: 1433-3023
    Keywords: Bladder retraining ; Incontinence ; Outpatient ; Physiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventy-four patients presenting with a mixed pattern of urinary symptoms were randomly allocated to undergo either inpatient or outpatient continence programs as initial treatment, without prior urodynamic investigation. Both programs consisted of physiotherapy, bladder retraining, fluid normalization, dietary advice and general support and advice. Nine out of 39 in the outpatient group and 8 out of the 35 of the impatient group failed to complete the study. There was a significant decrease in frequency, nocturia, number of incontinent episodes and visual analog scores for both groups. In addition the outpatients had a significant reduction in loss on pad testing, and a significantly greater improvement in their visual analog score. In each group 63% were cured or improved to the extent that they did not require further treatment. Staff costs per outpatient were half those for an inpatient. We conclude that outpatient conservative treatment as detailed above is a successful first-line treatment of urinary incontinence in women. It is as successful and possibly better than inpatient treatment, and is significantly cheaper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01901248
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cation permeation and blockade of ROMK1, a cloned renal potassium channel (1997)
    Springer
    Pflügers Archiv 434 (1997), S. 151-158 
    Details
    ISSN: 1432-2013
    Keywords: Key words Inward rectifier ; Voltage-dependent block ; Distal nephron ; Selectivity ; Anomalous mole fraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  ROMK1 is an inwardly rectifying K+ channel cloned from the outer medulla of rat kidney. We have determined the permeation and blocking characteristics for several monovalent cations in ROMK1 when expressed in Xenopus oocytes, using the two-electrode voltage-clamp technique. The selectivity sequence for monovalent cations as determined by reversal potential changes under bi-ionic conditions was K+ 〉 Rb+ 〉 Cs+ = NH4+ 〉〉 Na+ = Li+. The conductivity for the two permeant ions K+ and Rb+ was a saturable function of the external concentration, with K m values of 11.5 ± 1.3 mmol l–1 (n = 19) and 47.3 ± 4.8 mmol l–1 (n = 19), respectively. With mixtures of K+ and Rb+, the conductance went through a clear minimum as the concentration ratio [Rb]/[K+Rb] was varied between 0 and 1. ROMK1 was blocked by both Cs+ and Ba2+ in a concentration- and voltage-dependent manner. The electrical distance (δ) at which Ba2+ and Cs+ blocked the channel was 0.41 and 0.69, respectively, suggesting that these two ions block at different sites within the pore. Taken together with previous reports, the results indicate that ROMK1 has a multi-ion pore, and that the N-terminus contributes to the pore structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050377
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A randomized controlled trial of urodynamic investigations prior to conservative treatment of urinary incontinence in the female (1995)
    Springer
    International urogynecology journal 6 (1995), S. 277-281 
    Details
    ISSN: 1433-3023
    Keywords: Bladder retraining ; Incontinence ; Physiotherapy ; Urodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixty patients complaining of frequency, urgency, nocturia, urge incontinence and stress incontinence were randomly allocated to either undergo conservative treatment by way of combined physiotherapy and bladder retraining as an inpatient without prior urodynamics, or to have urodynamic investigations and treatment tailored to the urodynamic diagnosis. The assessment period was 3 months and assessment was made pre- and posttreatment by urinary diary, pad testing and subjective questionnaire. There was a significant improvement posttreatment for each parameter studied, with the exception of pad testing. There was no significant difference between the two groups for any parameter. Two-thirds of patients were cured to the extent that they did not require further treatment, and again there was no difference between the two groups. We conclude that patients attending for the first time with an uncomplicated story of urinary incontinence can be effectively treated conservatively without prior urodynamics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01901525
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    Paper (German National Licenses)
    Fulltext
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