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Digitale Medien

The effects of an anti-mitotic drug, bleomycin, on glial repair in an insect central nervous system (1986)

Treherne, J. E. ; Howes, E. A. ; Leech, C. A. ; [weitere]

Springer

Cell & tissue research 243 (1986), S. 375-384

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Details

ISSN: 1432-0878

Schlagwort(e): Glia ; Haemocyte ; Central nervous system ; Bleomycin ; Neural repair ; Insect, Periplaneta americana

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The DNA-binding drug, bleomycin, has a profound effect on neural repair following selective glial disruption by ethidium bromide. The contribution of the granule-containing cells (which normally appear in the early stages of repair) is greatly reduced, the restoration of the blood-brain barrier is delayed and the ultrastructural organization of the reorganising perineurium is dramatically changed. The aberrant perineurial structure and function observed in the presence of bleomycin are postulated to result from the effects of the drug on haemocytes which, together with endogenous reactive cells, contribute to the normal process of glial repair.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00251054

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