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  • 1
    Electronic Resource
    Electronic Resource
    Lupus anticoagulant associated syndrome in benign and malignant systemic disease (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 818-822 
    Details
    ISSN: 1432-1440
    Keywords: Lupus anticoagulant ; Systemic lupus erythematosus ; Paraproteinemia ; Lymphoproliferative diseases ; Multiple myeloma ; Myeloproliferative diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A strong correlation exists between the presence of an in vitro plasma coagulation inhibitor, named “lupus anticoagulant”, and a clinical syndrome of recurrent arterial and venous thromboses, neurological abnormalities, repeated obstetrical complications, thrombocytopenia, a biologic false-positive serological test for syphilis, and a variety of rarer manifestations. This syndrome has predominantly been observed in patients with autoimmune diseases, but it may be of similar importance in association with monoclonal gammopathies. As an introduction to a detailed analysis of ten observations which will also be published in this journal, this article reviews the clinical findings, the proposed pathogenetic mechanisms and the approaches to management of the lupus anticoagulant associated syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727476
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Immunophenotyping of B lymphocytes by multiparametric flow cytometry in bone marrow aspirates of healthy adults (1995)
    Springer
    Annals of hematology 71 (1995), S. 123-128 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin's lymphoma ; Lymphocyte immunophenotyping ; Multiparametric flow cytometry ; Live gate analysis ; Bone marrow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Establishing reference ranges by multiparametric immunophenotyping of mature B cells in bone marrow of healthy adults is of interest because the detection of bone marrow infiltration and persistence of light chain restriction, as well as discrimination between reactive and malignant lymphocytes are important applications of B-cell immunophenotyping. To determine the pattern of antigens as expressed by malignant mature B lymphocytes in the present study, bone marrow aspirates of healthy adults were investigated for the presence and percentage frequency of those antigens as defined for immunophenotyping of B cells by the REAL Classification. For this purpose, analysis of CD19-positive B lymphocytes by ‘live gate’ analysis was performed. The established two-color as well as threecolor stainings will serve as a basis for future investigations designed to test multiparametric analysis of B lymphocytes in bone marrow aspirates. All investigated antibodies stained with varying percentage frequency on B-cell subtypes, and no statistical significant difference was found between bone marrow aspirates of women and those of men. On the basis of this analysis, all the reported lineage antigen combinations are present both in malignant B lymphocytes and in normal B cells in considerable percentage frequency. These findings are of importance for follow-up investigations of patients with non-Hodgkin's lymphomas by multiparametric immunophenotyping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01702647
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Frequent association of idiopathic myelofibrosis with plasma cell dyscrasias (1988)
    Springer
    Annals of hematology 56 (1988), S. 97-102 
    Details
    ISSN: 1432-0584
    Keywords: Myelofibrosis ; Myeloproliferative diseases ; Paraproteinemia ; Multiple Myeloma ; Lymphoproliferative diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a retrospective analysis of 199 cases of myeloproliferative diseases a concomitant plasma cell dyscrasia was found in three out of 46 patients with idiopathic myelofibrosis. Chronic myeloid leukemia, polycythemia vera or unclassifiable myeloproliferative disorders were in no case associated with monoclonal gammopathy. One patient with idiopathic myelofibrosis had primarily coexistent IgG-λ paraproteinemia and increasing osteolytic lesions; histologic evidence of multiple myeloma, however, was insufficient. In the second patient the interval between diagnosis of idiopathic myelofibrosis and IgG-κ paraproteinemia was 11 years. After a stable period of 9 years' duration the paraprotein level rapidly increased, associated with depression of normal background immunoglobulins and progressive bone marrow failure. The exact nature of this patient's malignant plasma cell dyscrasia remained uncertain. In the third case benign monoclonal gammopathy of the IgM-λ type was diagnosed 13 years after idiopathic myelofibrosis. A review of the literature confirms a remarkably high incidence of monoclonal gammopathies in idiopathic myelofibrosis. Benign monoclonal gammopathy seems to occur in at least 8% of the patients while only a few cases of concomitant multiple myeloma have been reported. It may be speculated that plasma cell dyscrasias in idiopathic myelofibrosis reflect involvement of the lymphoid lineage in the neoplastic stem cell disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320010
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Immunophenotyping of B lymphocytes by multiparametric flow cytometry in bone marrow aspirates of healthy adults (1995)
    Springer
    Annals of hematology 71 (1995), S. 123-128 
    Details
    ISSN: 1432-0584
    Keywords: Key words Non-Hodgkin's lymphoma ; Lymphocyte immunophenotyping ; Multiparametric flow cytometry ; Live gate analysis ; Bone marrow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Establishing reference ranges by multiparametric immunophenotyping of mature B cells in bone marrow of healthy adults is of interest because the detection of bone marrow infiltration and persistence of light chain restriction, as well as discrimination between reactive and malignant lymphocytes are important applications of B-cell immunophenotyping. To determine the pattern of antigens as expressed by malignant mature B lymphocytes in the present study, bone marrow aspirates of healthy adults were investigated for the presence and percentage frequency of those antigens as defined for immunophenotyping of B cells by the REAL Classification. For this purpose, analysis of CD19-positive B lymphocytes by 'live gate' analysis was performed. The established two-color as well as three-color stainings will serve as a basis for future investigations designed to test multiparametric analysis of B lymphocytes in bone marrow aspirates. All investigated antibodies stained with varying percentage frequency on B-cell subtypes, and no statistical significant difference was found between bone marrow aspirates of women and those of men. On the basis of this analysis, all the reported lineage antigen combinations are present both in malignant B lymphocytes and in normal B cells in considerable percentage frequency. These findings are of importance for follow-up investigations of patients with non-Hodgkin's lymphomas by multiparametric immunophenotyping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01702647
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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