ISSN:
1432-0584
Keywords:
Aplastic anemia
;
Leukemia
;
Bone marrow morphology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We describe a patient with acute myeloid leukemia (AML) occurring 5 years after successful treatment of severe aplastic anemia (SAA) with antilymphocyte globulin (ALG). Four years after ALG, SAA had relapsed. A second remission of SAA was achieved, but was followed by transformation of the myelodysplastic syndrome into overt AML. After 2 courses of high-dose cytosine arabinoside and VP-16 complete remission occurred. This case shows that chemotherapy of secondary leukemia after SAA is feasible, and that ex-aplastic bone marrow is capable of complete recovery from chemotherapy-induced aplasia. Morphological anomalies of bone marrow noticed early during remission of SAA might predict a late transformation in leukemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00633468
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