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  • 1
    Electronic Resource
    Electronic Resource
    Effect of the menopause and hormone replacement therapy on the carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (1994)
    Springer
    Osteoporosis international 4 (1994), S. 349-352 
    Details
    ISSN: 1433-2965
    Keywords: Collagen ; Hormone replacement therapy ; Menopause ; Oestrogen ; Osteoporosis ; Procollagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effect of the menopause and postmenopausal hormone replacement therapy (HRT) on the serum concentration of carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP), a potential new biochemical marker of bone resorption. A group of 44 healthy postmenopausal women, aged 45–54 years, had about 19% higher serum ICTP than did a group of 42 healthy premenopausal women aged 35–50 years (3.6±0.8 µg/l v 3.0±0.7 µg/l (mean ±SD);p〈0.01), although there was a large overlap in the values. The 44 postmenopausal women also participated in a longitudinal clinical study, in which 20 received HRT and 24 received a placebo. Compared with the placebo group, those who received HRT had a significant (p〈0.05) decrease in ICTP of about 12% at the end of 1 year of treatment, but again there was considerable overlap in the values. The menopause-and HRT-induced changes in ICTP were less than those seen in serum osteocalcin, serum total alkaline phosphatase, and fasting urinary excretion of hydroxyproline, calcium, pyridinoline and deoxypyridinoline. We conclude that the menopause increases and HRT decreases ICTP, although these changes are less pronounced than those seen in other biochemical markers of bone turnover.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622196
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of the menopause and hormone replacement therapy on serum carboxyterminal propeptide of type I collagen (1993)
    Springer
    Osteoporosis international 3 (1993), S. 50-52 
    Details
    ISSN: 1433-2965
    Keywords: Collagen ; Gestogen ; Menopause ; Oestrogen ; Osteoporosis ; Procolgen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effect of the menopause and postmenopausal hormone replacement therapy on the serum concentration of carboxyterminal propeptide of type I procollagen (PICP), which is a biochemical marker of type I collagen synthesis. A group of 124 healthy postmenopausal women, aged 45–53 years, had about 20% higher serum PICP than did a group of 40 healthy premenopausal women aged 35–52 years (114±35 µg/1 vs. 95±26 µg/l (mean ± SD);p=0.002). The 124 postmenopausal women were also participating in a double-masked longitudinal study with two placebo groups and four different hormone replacement therapy groups. The four hormone regimens resulted in similar responses in serum PICP. Compared with placebo, 1 year of treatment with any of the four hormone replacement therapies significantly decreased serum PICP to premenopausal levels. We conclude that the formation of type I collagen is increased shortly after the menopause and that hormone replacement therapy reverses this increase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623177
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Osteopenia in insulin treated diabetes mellitus (1978)
    Springer
    Diabetologia 15 (1978), S. 87-90 
    Details
    ISSN: 1432-0428
    Keywords: Bone mineral content ; osteopenia ; diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone mineral content was measured by photon absorptiometry in 215 insulin treated diabetic out-patients aged 7–70 years. As bone mass increases until the age of 20–25 years, patients were so selected that all remained within the same phase of bone mineral storage throughout the entire course of their diabetes. Other criteria for exclusion were diseases or drugs interfering with mineral metabolism and previous use of oral antidiabetic agents. As a group the patients demonstrated a bone mineral deficit of 9.8% compared with sex- and age-matched controls (P〈0.001). Comparison between patients who had developed diabetes before the age of 20 years and after that of 25 years revealed deficits of 14% and 7%, respectively (P〈0.001). Sex differences were not observed. The initiation of osteopenia seemed to coincide with the onset of clinical diabetes mellitus, and significantly reduced bone mineral content was observed after 2 years of diabetes (P〈0.001). After 3–5 years the osteopenia appeared to attain a stable level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422250
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Bone loss in diabetes: Effects of metabolic state (1979)
    Springer
    Diabetologia 17 (1979), S. 283-286 
    Details
    ISSN: 1432-0428
    Keywords: Bone mineral content ; diabetes mellitus ; diabetic control ; insulin secretion ; insulin dosage ; fasting blood glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The significance of different risk factors for the development of bone loss in diabetes mellitus was evaluated in a cross sectional study of 215 insulin treated diabetic outpatients. Bone mineral content in the forearms was measured by photon absorptiometry and the metabolic status was evaluated by three indices: residual B-cell function, insulin dosage and fasting blood glucose. The mean bone mineral content was reduced to 90.2% of sex- and agematched normal mean values (P〈0.001). Stratification of the patients showed that bone mineral content was 99.3% of that found in sex- and age matched normal subjects in the group with residual B-cell function, low insulin dosage and low fasting blood glucose; it was only 79.3% of normal in the group with no detectable insulin secretion, high insulin dosage and more severe hyperglycaemia. Thus, residual insulin secretion and the quality of metabolic control are major factors in determining bone mineral content in insulin treated diabetic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01235883
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    Paper (German National Licenses)
    Fulltext
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